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Project 1

Koch, K.S., Maeda, S., He, G., Karin, M, Leffert, H.L. (2009) Targeted deletion of hepatocyte IKKβ; confers growth advantages. Biochemical and Biophysical Research Communications 380:349-354

PubMed ID: 19171122 | PubMed Central ID: PMC2663043

Naugler WE, Karin M. NF-KappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev. 18(1):19-26, 2008.

PubMed ID: 18440219 | PubMed Central ID: PMC2587362

Budanov AV, Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134(3):451-60, 2008. 

PubMed ID: 18692468

Sakurai, T., He, G., Matsuzawa, A., Yu, G.Y., Maeda, S., Hardiman, G., Karin, M.  Hepatocyte necrosis induced by oxidative stress and IL-1a release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell , 14: 156-65, 2008.

PubMed ID: 18691550 | PubMed Central ID: PMC2707922

Sell S, Leffert HL. Liver cancer stem cells. J Clin Oncol 26(17):2800-5, 2008.

PubMed ID: 18539957 | PubMed Central ID: PMC2515096

Naugler, W.E., Sakurai, T., Kim, S., Maeda, S., Kim, K., Elsharkawy, A.M., Karin, M. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317: 121-124, 2007.

PubMed ID: 17615358

Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M.  The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 124(3): 601-613, 2006.

PubMed ID: 16469705

Koch KS, Son KH, Maehr R, Pellicciotta I, Ploegh HL, Zanetti M, Sell S, Leffert HL. Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines. Immunology 119(1): 98-115, 2006.

PubMed ID: 16836618 | PubMed Central ID: PMC1782333

Sakurai T, Maeda S, Chang L, Karin M. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A 103(28):10544-51, 2006. 

PubMed ID: 16807293 | PubMed Central ID: PMC1502270

Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120: 649-61, 2005.

PubMed ID: 15766528

Karin M and Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5(10):  749-59, 2005.

PubMed ID: 16175180

Maeda S, Kamata H, Luo J-L, Leffert H, Karin M. IKKbeta; Couples Hepatocyte Cell Death to Cytokine-driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis. Cell 121:  977-990, 2005.

PubMed ID: 15989949
Project 2

Kennedy PJ, Vashisht AA, Hoe KL, Kim DU, Park HO, Hayles J, Russell P.
A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.Toxicol Sci. 106(1):124-39, 2008.

PubMed ID: 18684775 | PubMed Central ID: PMC2563147 (Available on 11/1/09)

Vashisht AA, Kennedy PJ, Russell P. Centaurin-like protein Cnt5 contributes to arsenic and cadmium resistance in fission yeast. FEMS Yeast Res. 2008 Dec 6. 

PubMed ID: 19076239

Martín V, Rodríguez-Gabriel MA, McDonald WH, Watt S, Yates 3rd JR, Bähler J, Russell P. Cip1 and Cip2 are novel RNA-Recognition-Motif proteins that counteract Csx1 function during oxidative stress. Mol. Biol. Cell 17:1176-1183, 2006.

PubMed ID: 16407405 | PubMed Central ID: PMC1382307

Rodríguez-Gabriel MA, Watt S, Bähler J, Russell P. Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast. Mol. Cell. Biol. 26: 6347-6356, 2006.

PubMed ID: 16914721 | PubMed Central ID: PMC1592850

Rodriguez-Gabriel MA, Russell P. Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe. Eukaryotic Cell 4(8):  1396-1402, 2005.

PubMed ID: 16087744 | PubMed Central ID: PMC1214538
Project 3

Stedman C, Liddle C, Coulter S, Sonoda J, Alvarez JG, Evans RM, and Downes M. Benefit of FXR inhibition in obstructive cholestasis. Proc. Natl. Acad. Sci. USA 103:11323-8, 2006.

PubMed ID: 16844773 | PubMed Central ID: PMC1544085

Sonoda J, Mehl IR, Chong LW, Nofsinger RR, Evans RM. PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc Natl Acad Sci USA. Mar 20;104(12): 5223-5228, 2007.

PubMed ID: 17360356 | PubMed Central ID: PMC1829290
Project 4

Nguyen, N., Bonzo, J.A., Chen, S., Chouinard, S., Kelner, M., Hardiman, G., Belanger, A., and Tukey, R.H. Disruption of the Ugt1 locus in mice resembles human Crigler-Najjar type I disease. J. Biol. Chem. 283:7901-7911, 2008.

PubMed ID: 18180294

Bonzo, J.A., Belanger, A., and Tukey, R.H. The role of chrysin and the Ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology, 45: 349-360, 2007.

PubMed ID: 17256720

Operaña TN, Nguyen N, Chen S, Beaton D and Tukey RH. Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicological Sciences 95: 98-107, 2007.

PubMed ID: 17065433

Senekeo-Effenberger, K., Chen, S., Yueh, M-F., Erace-Sinnokrak, E., Bonzo, J.A., Argikar, U., Kaeding, J., Trottier, T., Remmel, R.P., Ritter, J.K., Barbier, O., and Tukey, R.H. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Met. Disp. 35: 419-427, 2007.

PubMed ID: 17151188

Yueh, M-F. and Tukey, R.H. Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J. Biol. Chem. 282: 8749-8758, 2007.

PubMed ID: 17259171

Verreault, M., Senekeo-Effenberger, K., Trottier, J., Bonzo, J.A., Belanger, J., Kaeding, J., Staels, B., Caron, P., Tukey, R.H. and Barbier, O. The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Hepatology, 44: 367-378, 2006. 

PubMed ID: 16871576

Bonzo JA, Chen S, Galijatovic A, Tukey RH. Arsenite inihibition of CYP1A1 induction by TCDD is independent of cell cycle arrest. Mol. Pharm. 67:  1247-1256, 2005.

PubMed ID: 15630080

Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter J, Tukey RH. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltranserase-1 (UGT1) locus. J. Biol. Chem. 280: 37547-37557, 2005.

PubMed ID: 16155002

Chen S, Operana T, Bonzo J, Nguyen N, Tukey RH. Erk kinase inhibition stabilizes the aryl hydrocarbon receptor. J. Biol. Chem. 280:  4350-4359, 2005.

PubMed ID: 15572374

Machemer DEW and Tukey RH. The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicological Sciences 87:  27-37, 2005.

PubMed ID: 15947024
Project 6

Boudinot E, Bernard V, Camp S, Taylor P, Champagnat J, Krejci E, Foutz AS. Influence of differential expression of acetylcholinesterase in brain and muscle on respiration. Respir Physiol Neurobiol. 165(1):40-8, 2009.

PubMed ID: 18977317

Dobbertin A, Hrabovska A, Dembele K, Camp S, Taylor P, Krejci E, Bernard V. Targeting of acetylcholinesterase in neurons in vivo: a dual processing function for the proline-rich membrane anchor subunit and the attachment domain on the catalytic subunit. J Neurosci. 29(14):4519-30, 2009.

PubMed ID: 19357277 | PubMed Central ID: PMC2695489 (Available 4/8/10)

Camp, S., De Jaco, A., Zhang, L., Marquez, M., De Lar Torre, B., and Taylor, P. Acetylcholinesterase Expression in Muscle is Specifically Controlled by a Promoter-Selective Enhancesome. J. Neuroscience 28(10):2459-2470, 2008.

PubMed ID: 18322091 | PubMed Central ID: PMC2692871

Comoletti D, Grishaev A, Whitten AE, Taylor P, Trewhella J.  Characterization of the solution structure of a neuroligin/beta-neurexin complex.  Chem Biol Interact. Sep 25;175(1-3):150-5, 2008.  Epub 2008 May 4.

PubMed ID: 18550038 | PubMed Central ID: PMC2587492 (Available 9/25/09)

De Jaco A, Comoletti D, King CC, Taylor P.Trafficking of cholinesterases and neuroligins mutant proteins. An association with autism.  Chem Biol Interact. Sep 25;175(1-3):349-51, 2008. Epub 2008 Apr 29.

PubMed ID: 18555979 | PubMed Central ID: PMC2692863

Comoletti D, Grishaev A, Whitten A, Tsigelny I, Taylor P, Trewhella J. Synaptic arrangement of the neuroligin/beta-neurexin complex revealed by X-ray and neutron scattering.  Structure 15(6): 693-705, 2007.

PubMed ID: 17562316 | PubMed Central ID: PMC2677967

Fabrichny, IP., Leone, P., Salzanbacher, G., Comoletti, D., Miller, MT., Taylor, P., Bourne, Y., and Marchot, P. Structural Analysis of the Synaptic Protein Neuroligin and its beta-Neurexin Complex: Determinants for Folding and Cell Adhesion. Neuron, 56, 979-91. (2007).

PubMed ID: 18093521

Comoletti D, Flynn RE, Boucard AA, Demeler B, Schirf V, Shi J, Jennings LL, Newlin HR, Südhof TC and Taylor P.  Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins.  Biochemistry 45:12816-12827, 2006.

PubMed ID: 17042500

De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor, P.  A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family. J. Biol. Chem.281(14):9667-76, 2006.

PubMed ID: 16434405

Shi J, Koeppe JR, Komives EA, Taylor P. Ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometry. J Biol Chem. 281(17):12170-7, 2006.

PubMed ID: 16484218

Comoletti D, De Jaco A, Jennings LL, Flynn RE, Gaietta G, Tsigelny I, Ellisman MH, Taylor P. The Arg451 Cys-Neuroligin-3 Mutation Associated with Autism reveals a Defect in Protein Processing. J. Neuro 24 (20):  4889-4893, 2004.

PubMed ID: 15152050
Project 7

Kim, Y.Y., Kim, D.Y., Shim, D., Song, W.Y., Lee, J., Schroeder, J.I., Kim, S., Moran, N., Lee Y. Expression of the Novel Wheat Gene TM20 Confers Enhanced Cadmium Tolerance to Bakers Yeast.JBiolChem.283:15893-15892(2008).

PubMed ID: 18411273 | PubMed Central ID: PMC2414300

Mendoza-Cozatl DG, Butko E, Springer F, Torpey JW, Komives EA, Kehr J, Schroeder JI.  Identification of high levels of phytochelatins, glutathione and cadmium in the phloem sap of Brassica napus. A role for thiol-peptides in the long-distance transport of cadmium and the effect of cadmium on iron translocation. Plant Journal 54: 249-59, 2008.

PubMed ID: 18208526

Vahisalu, T., Kollist, H., Wang, Y.‐F., Nishimura, N., Chan, W.‐Y., Valerio, G., Lamminmaki, A., Brosche, M., Moldau,
H., Desikan, R., Schroeder, J.I., Kangasjarvi, J. SLAC1 is required for plant guard cell S‐type anion channel function in
stomatal signalling. Nature 452:487‐91 (2008).

PubMed ID: 18305484

Sadi BB, Vonderheide AP, Gong JM, Schroeder JI, Shann JR, Caruso JA.  An HPLC-ICP-MS technique for determination of cadmium-phytochelatins in genetically modified Arabidopsis thaliana.  J Chromatogr B Analyt Technol Biomed Life Sci.  861: 123-129 (2008).

PubMed ID: 18065298

Horie, T., Costa, A., Kim, TH, Han, MH, Horie, R., Leung, HY, Miyao, A., Hirochika, H., An, G. and Schroeder, J.I. Rice OsHKT2;1 transporter mediates large Na+ influx component into K+-starved roots for growth. EMBO J. 26: 3003-3014, 2007.

PubMed ID: 17541409 | PubMed Central ID: PMC1894770

Sung DY, Lee D, Harris H, Raab A, Feldmann J, Meharg A, Kumabe B, Komives EA, Schroeder JI.  Identification of an arsenic tolerant double mutant with a thiol-mediated component and increased arsenic tolerance in phyA mutants. Plant J.  49:1064-1075, 2007.

PubMed ID: 17335514

Imaizumi T, Kay SA, Schroeder JI. Circadian rhythms. Daily watch on metabolism. Science: 318: 1730-1731, 2007.

PubMed ID: 18006706

Imaizumi T, Schroeder JI, Kay SA. In SYNC: the ins and outs of circadian oscillations in calcium. Sci STKE: 390: pe32, 2007.

PubMed ID: 17565121

Chen A, Komives EA, Schroeder JI. An improved grafting technique for mature Arabidopsis plants demonstrates long-distance shoot-to-root transport of phytochelatins in Arabidopsis. Plant Physiology 141: 108-120, 2006.

PubMed ID: 16531489 | PubMed Central ID: PMC1459314

Kwak JM, Nguyen V, Schroeder JI. The role of reactive oxygen species in hormonal responses. Plant Physiology 141: 323-329, 2006.

PubMed ID: 16760482 | PubMed Central ID: PMC1475468

Platten JD, Cotsaftis O, Berthomieu P, Bohnert H, Davenport RJ, Fairbairn DJ, Horie T, Leigh RA, Lin HX, Luan S, Maser P, Pantoja O, Rodriguez-Navarro A, Schachtman DP, Schroeder JI, Sentenac H, Uozumi N, Very AA, Zhu JK, Dennis ES, Tester M. Nomenclature for HKT transporters, key determinants of plant salinity tolerance. Trends Plant Sci. 11: 372-374, 2006.

PubMed ID: 16809061

Schroeder JI, Nambara E. A quick release mechanism for abscisic acid. Cell 126: 1023-1025, 2006.

PubMed ID: 16990126

Schroeder JI, Kuhn JM. Plant biology abscisic acid in bloom. Nature 439: 277-278, 2006.

PubMed ID: 16421556

Sunarpi, Horie T, Motoda J, Kubo M, Yang H, Yoda K, Horie R, Chan W, Leung H-Y, Hattori K, Konomi M, Osumi M, Yamagami M, *Schroeder JI, *Uozumi N. (* corresponding authors) Enhanced salt tolerance mediated by AtHKT1 transporter-induced Na+ unloading from xylem parenchyma cells. Pl. Journal 44:  928-938, 2005.

PubMed ID: 16359386

Gong JM, Waner DA, Horie T, Li SL, Horie R, Abid KB, Schroeder JI. Microarray-based rapid cloning of an ion accumulation deletion mutant in Arabidopsis thaliana. Proc. Natl. Acad. Sci (USA) 101:  15404-15409, 2004.

PubMed ID: 15486089 | PubMed Central ID: PMC524449

Li Y, Dhankher OP, Carreira L, Lee D, Chen A, Schroeder JI, Balish RS, Meagher RB. Overexpression of phytochelatin synthase in Arabidopsis leads to enhanced arsenic tolerance and cadmium hypersensitivity. Plant Cell Physiol. 45:  1787-1797, 2004.

PubMed ID: 15653797

Mori I and Schroeder JI.  Reactive Oxygen Species Activation of Plant Ca2+ Channels: A Signaling Mechanism in Polar Growth, Hormone Transduction, Stress Signaling, and Hypothetically Mechano-transduction. Plant Physiology 135(2):  702-708, 2004.

PubMed ID: 15208417 | PubMed Central ID: PMC514107

Wycisk K, Kim EJ, Schroeder JI, Kramer U. Enhancing the First Enzymatic Step in Histidine Biosynthesis Pathway Increases the Free Histidine Pool and Nickel Tolerance in Arabidosis Thaliana. FEBS Letters 578: 128-134, 2004.

PubMed ID: 15581629
Project 8

Anderson CR, Johnson HA, Caputo N, Davis RE, Torpey JW, Tebo BM. Mn(II) oxidation is catalyzed by heme peroxidases in “Aurantimonas manganoxydans” strain SI85-9A1 and Erythrobacter sp. strain SD-21. Appl Environ Microbiol 75(12):4130-4138, 2009.

PubMed ID: 19411418

Dick GJ, Podell S, Johnson HA, Bernier-Latmani R, McCarthy JK, Rivera Espinosa Y, Clement BG, Torpey JW, Gaasterland T, and Tebo BM. Genomic insights into Mn(II) oxidation by Aurantimonas sp. strain SI85-9A1, a globally distributed marine Mn(II)-oxidizing alpha-proteobacterium. Applied and Environmental Microbiology 74(9):2646-58, 2008.

PubMed ID: 18344346 | PubMed Central ID: PMC2394881

Dick GJ, Torepy JW, Beveridge TJ and Tebo BM.  Direct identification of a bacterial manganese(II) oxidase: The multicopper oxidase MnxG.  Applied and Environmental Microbiology 74(5):1527-34,2008.

PubMed ID: 18165363 | PubMed Central ID: PMC2258647

Johnson, H.A. and B.M. Tebo (2008).  In vitro studies indicate the bacterial Mn(II)-oxidizing protein is a quinoprotein.  Archives of Microbiology 189:59-69.

PubMed ID: 17673976

Bencheikh-Latmani R, Obraztsova A, Mackey M, Ellisman M, and Tebo BM.  Toxicity of Cr (III) to Shewanella sp. Strain MR-4 during Cr(VI) reduction.  Environmental Science & Technology 41(1):214-220, 2007. 

PubMed ID: 17265950

Murray KJ and Tebo BM. Cr(III) is indirectly oxidized by the Mn(II)-oxidizing bacterium Bacillus sp. strain SG-1.  Environmental Science & Technology 41:528-533, 2007

PubMed ID: 17310717

Dick GJ, Lee YE, Tebo BM. Manganese(II)-oxidizing Bacillus spores in Guaymas Basin hydrothermal sediments and plumes. Appl Environ Microbiol 72(5):3184-90, 2006.

PubMed ID: 16672456 | PubMed Central ID: PMC1472353

Bencheikh-Latmani R, Williams SM, Haucke L, Criddle CS, Wu L, Zhou J, Tebo BM.  Global transcriptional profiling of Shewanella oneidensis MR-1 during Cr(VI) and U(VI) reduction.  Applied and Environmental Microbiology 71:  7453-7460, 2005.

PubMed ID: 16269787 | PubMed Central ID: PMC1287662

Tebo BM, Johnson HA, McCarthy JK, Templeton AS.  Geomicrobiology of manganese(II) oxidation.  Trends in Microbiology 13:  421-428, 2005.

PubMed ID: 16054815
Tools and Resources
currently no publications
Mouse Genetics Core
currently no publications
Protein Characterization Core
currently no publications
Molecular Imaging Core

Perkins G, Bossy-Wetzel E, and Ellisman MH. New insights into mitochondrial structure during cell death. Exp Neurol, 218:183-192, 2009.

PubMed ID: 19464290

Knott, A.B., Perkins, G., Schwarzenbacher, R. and Bossy-Wetzel, E.  Break Up: Mitochondrial Fragmentation In Neurodegeneration. Nature Reviews Neuroscience, 9:505-518, 2008.

PubMed ID: 18568013

Yamaguchi R, Lartigue L, Perkins G, Scott RT, Dixit A, Kushnareva Y, Kuwana T, Ellisman MH, Newmeyer DD. Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Mol Cell. 2008 Aug 22;31(4):557-69. Epub 2008 Aug 7.

PubMed ID: 18691924 | PubMed Central ID: PMC2636708 (Available 8/22/09)
Administration Core
currently no publications
Research Translation Core

Pezzoli K, Tukey R, Sarabia H, Zaslavsky I, Miranda ML, Suk WA, Lin A and Ellisman M. In Press. The NIEHS Environmental Health Sciences Data Resource Portal: Placing Advanced Technologies in Service to Vulnerable Communities. Environmental Health Perspectives 115(4):564-71, 2007.

PubMed ID: 17450225 | PubMed Central ID: PMC1852670
Community Outreach Core

Sarabia, H. 2008. “Toxics in Tijuana’s Laureles Canyon: Irregular Settlements, Human Health and Ecosystem Integrity” GPEIG:Newsletter of the Global Planning Educators Interest Group. Summer 2008. pp. 15-16

PubMed ID: http://www.gpeig.org/index.php/resources/newsletters

Sarabia, H. 2008. “Indigenous People and Toxics in the U.S.-Mexico Border and Latin America” GPEIG:Newsletter of the Global Planning Educators Interest Group. Summer 2008. pp. 13-14

PubMed ID: http://www.gpeig.org/index.php/resources/newsletters
Training Core

Senekeo-Effenberger, K., Chen, S., Yeuh, M-F., Brace-Sinnokrak, E., Bonzo, JA., Argikar, U., Kaeding, J., Trottier, J., Remmel, RP., Ritter, JK., and Tukey, RH. Expression of the Human UGT1 Locus in Transgenic Mice by WY-14643 and Implicatoins on Drug Metabolism Through PPARα Activation. Drug Metabol. Dispos., 35:419-27, 2007. 

PubMed ID: 17151188