Superfund Research Program

Project 1: He G, Yu G-Y, Temkin V, Ogata H, Kuntzen C, Sakurai T, Sieghart W, Peck-Radosavlijevic M, Leffert HL, Karin M. Hepatocyte IKKB/NF-KB inhibits tumor promotion and progression by preventing oxidative stress driven STAT3 activation. Cancer Cell 17(3): 286-297, 2010. PMC2841312; PubMed ID: 20227042 | PubMed Central ID: PMC2841312 (Avail 3/16/11); Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. Sestrins as a feedback inhibitor of TOR that prevents age-related patholigies. Science 327: 1223-1228, 2010. PMC2866632; PubMed ID: 20203043 | PubMed Central ID: PMC2866632 (Avail 3/5/11); Park E, Lee J, Yu GY, He G, Ali S, Holzer R, Osterreicher C, Takahashi H, Karin M. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140:197-208, 2010. PMC2836922; PubMed ID: 20141834 | PubMed Central ID: PMC2836922 (Avail 1/22/11); Takahashi H, Ogata H, Nishigaki R, Broide DH, Karin M. Tobacco smoke promotes lung tumorigenesis by triggering IKKb and JNK1 dependent inflammation. Cancer Cell 17:89-97, 2010. PMC2818776; PubMed ID: 20129250 | PubMed Central ID: PMC2818776 (Avail 1/19/11); Koch, K.S., Maeda, S., He, G., Karin, M, Leffert, H.L. (2009) Targeted deletion of hepatocyte IKKβ; confers growth advantages. Biochemical and Biophysical Research Communications 380:349-354. OMC2663043; PubMed ID: 19171122 | PubMed Central ID: PMC2663043; Naugler WE, Karin M. NF-KappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev. 18(1):19-26, 2008. PMC2587362; PubMed ID: 18440219 | PubMed Central ID: PMC2587362; Budanov AV, Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134(3):451-60, 2008. PMC2758522; PubMed ID: 18692468 | PubMed Central ID: PMC2758522; Sakurai, T., He, G., Matsuzawa, A., Yu, G.Y., Maeda, S., Hardiman, G., Karin, M. Hepatocyte necrosis induced by oxidative stress and IL-1a release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell , 14: 156-65, 2008. PMC2707922; PubMed ID: 18691550 | PubMed Central ID: PMC2707922; Sell S, Leffert HL. Liver cancer stem cells. J Clin Oncol 26(17):2800-5, 2008. PMC2515096; PubMed ID: 18539957 | PubMed Central ID: PMC2515096; Naugler, W.E., Sakurai, T., Kim, S., Maeda, S., Kim, K., Elsharkawy, A.M., Karin, M. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317: 121-124, 2007.; PubMed ID: 17615358; Drew D, Shimada E, Huynh K, Bergqvist S, Talwar R, Karin M, Ghosh G. Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma. Biochemistry 46(43): 12482-90, 2007.; PubMed ID: 17924664; Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 124(3): 601-613, 2006.; PubMed ID: 16469705; Koch KS, Son KH, Maehr R, Pellicciotta I, Ploegh HL, Zanetti M, Sell S, Leffert HL. Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines. Immunology 119(1): 98-115, 2006.; PubMed ID: 16836618 | PubMed Central ID: PMC1782333; Sakurai T, Maeda S, Chang L, Karin M. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A 103(28):10544-51, 2006.; PubMed ID: 16807293 | PubMed Central ID: PMC1502270; Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120: 649-61, 2005.; PubMed ID: 15766528; Karin M and Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5(10): 749-59, 2005.; PubMed ID: 16175180; Maeda S, Kamata H, Luo J-L, Leffert H, Karin M. IKKbeta; Couples Hepatocyte Cell Death to Cytokine-driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis. Cell 121: 977-990, 2005.; PubMed ID: 15989949

Project 2: Mendoza-Cozatl, D., Zhai, Z., Jobe, T., G.Z., A., Song, W. Y., Limbo, O., Russell, M., Kozlovskyy, V., Martinoia, E., Vatamaniuk, O. K., Russell, P. & Schroeder, J. I. 2010. Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. J. Biol. Chem. 285, 40416-40426. PMC3003340; PubMed ID: 20937798 | PubMed Central ID: PMC3003340 (Available on 2011/12/24); Kennedy PJ, Vashisht AA, Hoe KL, Kim DU, Park HO, Hayles J, Russell P.
A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.Toxicol Sci. 106(1):124-39, 2008. PMC2563147; PubMed ID: 18684775 | PubMed Central ID: PMC2563147; Rodriguez-Gabriel, MA, Russell, P. Control of mRNA stability by SAPKs. Topics Curr. Genet. 20: 50-166, 2008.; PubMed ID: Link to Pub; Vashisht AA, Kennedy PJ, Russell P. Centaurin-like protein Cnt5 contributes to arsenic and cadmium resistance in fission yeast. FEMS Yeast Res. 9, 257-269, 2009. PMC2820371; PubMed ID: 19076239 | PubMed Central ID: PMC2820371; Martín V, Rodríguez-Gabriel MA, McDonald WH, Watt S, Yates 3rd JR, Bähler J, Russell P. Cip1 and Cip2 are novel RNA-Recognition-Motif proteins that counteract Csx1 function during oxidative stress. Mol. Biol. Cell 17:1176-1183, 2006.; PubMed ID: 16407405 | PubMed Central ID: PMC1382307; Rodríguez-Gabriel MA, Watt S, Bähler J, Russell P. Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast. Mol. Cell. Biol. 26: 6347-6356, 2006.; PubMed ID: 16914721 | PubMed Central ID: PMC1592850; Rodriguez-Gabriel MA, Russell P. Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe. Eukaryotic Cell 4(8): 1396-1402, 2005.; PubMed ID: 16087744 | PubMed Central ID: PMC1214538

Project 3: Kacevska, M., Downes, M., Sharma, R., Evans, R.M., Clarke, S.J., Liddle, C., Robertson, G.R. Extrahepatic Cancer suppresses nuclear receptor regulated drug metabolism. Clinical Cancer Research 17(10):3170-80, 2011. PMC3096719 (Available on 2012/5/15); PubMed ID: 21498392; Sonoda J, Laganiere J, Mehl IR, Barish GD, Chong LW, Li X, Scheffler IE, Mock DC, Bataille AR, Robert F, Lee CH, Giguere V, Evans RM. Nuclear receptor ERRa and coactivator PGC-1b are effectors of IFN-g-induced host defense. Genes & Development 21(15): 1909-1920, 2007. PMC1935029; PubMed ID: 17671090 | PubMed Central ID: PMC1935029; Sonoda J, Mehl IR, Chong LW, Nofsinger RR, Evans RM. PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc Natl Acad Sci USA. Mar 20;104(12): 5223-5228, 2007. PMC1829290; PubMed ID: 17360356 | PubMed Central ID: PMC1829290; Stedman C, Liddle C, Coulter S, Sonoda J, Alvarez JG, Evans RM, and Downes M. Benefit of FXR inhibition in obstructive cholestasis. Proc. Natl. Acad. Sci. USA 103:11323-8, 2006. PMC1544085; PubMed ID: 16844773 | PubMed Central ID: PMC1544085

Project 4

Yueh MF, Mellon PL, Tukey RH. Inhibition of Human UGT2B7 Gene Expression in Transgenic Mice by the Constitutive Androstane Receptor. Molecular Pharmacology 79(6):1053-60, 2011. PMC3102552 [Available on 2012/6/1]

PubMed ID: 21415305

Cai H, Nguyen N, Peterkin V, Young-Sun Y, Hotz K, Beaton-La Placa D, Chen S. Tukey RH, and Stevens JC. A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1 dependent glucuronidation. Drug Metabol Dispos 38(5): 879-86, 2010. PMC2872941

PubMed ID: 20124398 | PubMed Central ID: PMC2872941 (Avail 5/1/11)

Fujiwara R, Nguyen N, Chen S, Tukey RH. Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP-glucuronosyltransferase 1 (UGT1) locus. Proc Natl Acad Sci USA 107(11): 5024-5029, 2010. PMC2841904 (Avail 9/16/10)

PubMed ID: 20194756 | PubMed Central ID: PMC2841904 (Avail 9/16/10)

Savas U, Machemer DE, Hsu MH, Gaynor P, Lasker JM, Tukey RH, Johnson EF. Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. J Biol Chem 284: 16541-16552, 2009. PMC2713544

PubMed ID: 19366684 | PubMed Central ID: PMC2713544

Argikar UA, Senekeo-Effenberger K, Larson EE, Tukey RH, Remmel RP. Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica 39:826-835, 2009. PMC2891280

PubMed ID: 19845433 | PubMed Central ID: PMC2891280

Nguyen, N., Bonzo, J.A., Chen, S., Chouinard, S., Kelner, M., Hardiman, G., Belanger, A., and Tukey, R.H. Disruption of the Ugt1 locus in mice resembles human Crigler-Najjar type I disease. J. Biol. Chem. 283:7901-7911, 2008.

PubMed ID: 18180294

Bonzo, J.A., Belanger, A., and Tukey, R.H. The role of chrysin and the Ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology, 45: 349-360, 2007.

PubMed ID: 17256720

Operaña TN, Nguyen N, Chen S, Beaton D and Tukey RH. Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicological Sciences 95: 98-107, 2007.

PubMed ID: 17065433

Senekeo-Effenberger, K., Chen, S., Yueh, M-F., Erace-Sinnokrak, E., Bonzo, J.A., Argikar, U., Kaeding, J., Trottier, T., Remmel, R.P., Ritter, J.K., Barbier, O., and Tukey, R.H. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Met. Disp. 35: 419-427, 2007.

PubMed ID: 17151188

Yueh, M-F. and Tukey, R.H. Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J. Biol. Chem. 282: 8749-8758, 2007.

PubMed ID: 17259171

Operana TN and Tukey RH. Oligomerization of the UDP-glucuronosyltranferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J Biol Chem 282: 4821-9, 2007.

PubMed ID: 17179145

Verreault, M., Senekeo-Effenberger, K., Trottier, J., Bonzo, J.A., Belanger, J., Kaeding, J., Staels, B., Caron, P., Tukey, R.H. and Barbier, O. The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Hepatology, 44: 367-378, 2006.

PubMed ID: 16871576

Bonzo JA, Chen S, Galijatovic A, Tukey RH. Arsenite inihibition of CYP1A1 induction by TCDD is independent of cell cycle arrest. Mol. Pharm. 67: 1247-1256, 2005.

PubMed ID: 15630080

Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter J, Tukey RH. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltranserase-1 (UGT1) locus. J. Biol. Chem. 280: 37547-37557, 2005.

PubMed ID: 16155002

Chen S, Operana T, Bonzo J, Nguyen N, Tukey RH. Erk kinase inhibition stabilizes the aryl hydrocarbon receptor. J. Biol. Chem. 280: 4350-4359, 2005.

PubMed ID: 15572374

Machemer DEW and Tukey RH. The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicological Sciences 87: 27-37, 2005.

PubMed ID: 15947024

Project 6: Miller, M.T., Mileni, M., Comoletti, D., Stevens, R.C., Harel, M., Taylor, P. (2011) The Crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function. Structure 19(6):767-78, 2011. PMC Pending; PubMed ID: 21620717; Leone, P., Comoletti, D., Taylor, P., Bourne, Y., and Marchot, P. (2010). Structure-function relationships of the alpha beta-hydrolase fold domain of neuroligin: A comparison with acetylcholinesterase. Chem-Biol. Interact., 187: 49-55 PMC Pending; PubMed ID: 20100470; De Jaco, A., Lin, M.Z., Dubi, N., Comoletti, D., Miller, M.T., Camp, S., Ellisman, M., Butko, M.T., Tsein, R.Y., Taylor, P, (2010) Neuroligin Trafficking Deficiencies Arising from Mutations in the alpha/beta-Hydrolase Fold Protein Family. J Biol Chem 285, 37 :28674-28682 PMC2937894; PubMed ID: 20615874; Leone, P., Comoletti, D., Ferracci, G., Conrod, D., Garcia, S., Taylor, P., Bourne, Y., and Marchot, P. (2010) Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. EMBO Journal, 29:2461-2471. PMC2910273; PubMed ID: 20543817; Wang, X., Lee, J., Di Jeso, B., Treglia, A.S., Comoletti, D., Dubi, N., Taylor, Plk and Arvan, P. (2010) Cis and trans actions of the cholinesterase-like domain within the thyroglobulin dimer. J Biol Chem 285, 23:17564-17573. PMC2878521; PubMed ID: 20353937; Comoletti, D., Miller, M., Jeffries, C.M., Wilson, J., Demeler, B., Taylor, P., Trewhella, J., and Nakagawa, T. (2010) The macromolecular architecture of the extracellular domain of alpha-NRXN1: domain organization, flexibility, and insights into trans-synaptic disposition. Structure 18, 1044-1053 PMC2948785; PubMed ID: 20696403; Camp S, Zhang L, Krejci E, Dobbertin A, Bernard V, Girard E, Duysen EG, Lockridge O, De Jaco A, Taylor P. Contributions of selective knockout studies to understanding cholinesterase disposition and function. Chem Biol Interact Epub Ahead of Print, 2010.; PubMed ID: 20153304; Boudinot E, Bernard V, Camp S, Taylor P, Champagnat J, Krejci E, Foutz AS. Influence of differential expression of acetylcholinesterase in brain and muscle on respiration. Respir Physiol Neurobiol. 165(1):40-8, 2009.; PubMed ID: 18977317 | PubMed Central ID: PMC2706911; Dobbertin A, Hrabovska A, Dembele K, Camp S, Taylor P, Krejci E, Bernard V. Targeting of acetylcholinesterase in neurons in vivo: a dual processing function for the proline-rich membrane anchor subunit and the attachment domain on the catalytic subunit. J Neurosci. 29(14):4519-30, 2009.; PubMed ID: 19357277 | PubMed Central ID: PMC2695489 (Available 4/8/10); Camp, S., De Jaco, A., Zhang, L., Marquez, M., De Lar Torre, B., and Taylor, P. Acetylcholinesterase Expression in Muscle is Specifically Controlled by a Promoter-Selective Enhancesome. J. Neuroscience 28(10):2459-2470, 2008.; PubMed ID: 18322091 | PubMed Central ID: PMC2692871; Comoletti D, Grishaev A, Whitten AE, Taylor P, Trewhella J. Characterization of the solution structure of a neuroligin/beta-neurexin complex. Chem Biol Interact. Sep 25;175(1-3):150-5, 2008. PMC2587492; PubMed ID: 18550038 | PubMed Central ID: PMC2587492; De Jaco A, Comoletti D, King CC, Taylor P.Trafficking of cholinesterases and neuroligins mutant proteins. An association with autism. Chem Biol Interact. Sep 25;175(1-3):349-51, 2008. PMC2692863; PubMed ID: 18555979 | PubMed Central ID: PMC2692863; Comoletti D, Grishaev A, Whitten A, Tsigelny I, Taylor P, Trewhella J. Synaptic arrangement of the neuroligin/beta-neurexin complex revealed by X-ray and neutron scattering. Structure 15(6): 693-705, 2007.; PubMed ID: 17562316 | PubMed Central ID: PMC2677967; Fabrichny, IP., Leone, P., Salzanbacher, G., Comoletti, D., Miller, MT., Taylor, P., Bourne, Y., and Marchot, P. Structural Analysis of the Synaptic Protein Neuroligin and its beta-Neurexin Complex: Determinants for Folding and Cell Adhesion. Neuron, 56, 979-91. (2007). PMC2703725PMC2677967; PubMed ID: 18093521; Comoletti D, Flynn RE, Boucard AA, Demeler B, Schirf V, Shi J, Jennings LL, Newlin HR, Südhof TC and Taylor P. Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins. Biochemistry 45:12816-12827, 2006.; PubMed ID: 17042500; De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor, P. A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family. J. Biol. Chem.281(14):9667-76, 2006.; PubMed ID: 16434405; Shi J, Koeppe JR, Komives EA, Taylor P. Ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometry. J Biol Chem. 281(17):12170-7, 2006.; PubMed ID: 16484218; Comoletti D, De Jaco A, Jennings LL, Flynn RE, Gaietta G, Tsigelny I, Ellisman MH, Taylor P. The Arg451 Cys-Neuroligin-3 Mutation Associated with Autism reveals a Defect in Protein Processing. J. Neuro 24 (20): 4889-4893, 2004.; PubMed ID: 15152050

Project 7

Hauser, F. Waadt, R. & Schroeder, J.I.. Evolution of abscisic acid synthesis and signaling mechanisms. Curr Biol. 10;21(9):R346-55, 2011. PMC Pending

PubMed ID: 21549957

Böhmer, M. & Schroeder, J. I. Quantitative transcriptomic analysis of ABA-induced and ROSdependent expression changes and proteomic profiling in Arabidopsis suspension cells Plant Journal 10.1111/j.1365-313X.2011.04579.x. Epub ahead of Print, 2011. PMCID-Pending

PubMed ID: 21426425

Song*, W.Y., Park*, J., Mendoza-Cózatl*, D.G., Suter-Grotemeyer, M., Shim, D., Hörtensteiner, S., Geisler, M., Weder, B., Rea, P.A., Rentsch, D., Schroeder, J.I., Lee#, Y., Martinoia, E. Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters. Proc. Natl. Acad. Sci. (USA) 107: 21187-92 (2010). PMC21078981.

PubMed ID: 21078981

Mendoza-Cozatl, D.G., Zhai, Z., Jobe, T.O., Akmakjian, G.Z., Song, W.Y., Limbo, O., Russell, M.R., Kozlovskyy, V.I., Martinoia, E., Vatamaniuk, O.K., Russell, P., Schroeder, J.I. Tonoplast-localized Abc2 Transporter Mediates Phytochelatin Accumulation in Vacuoles and Confers Cadmium Tolerance. J. Biol. Chem. 285: 40416-26 (2010). PMC3003340.

PubMed ID: 20937798

Li, J-Y., Fu, Y-L., Pike, S.M., Bao, J., Tian, W., Zhang, Y., Chen, C-Z., Zhang, Y., Li, H-M., Huang, J., Li, L-G., Schroeder, J.I., Gassmann, W., Gong, J-M. The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal from the xylem and mediates cadmium tolerance. Plant Cell 22: 1633-46 (2010). PMC2899866.

PubMed ID: 20501909

Pyo, Y.J., Gierth, M., Schroeder, J.I., Cho, M.H. High-affinity K+ transport in Arabidopsis: AtHAK5 and AKT1 are vital for seedling establishment and postgermination growth under low-potassium conditions. Plant Physiol. 153: 863-75 (2010). PMC2879780

PubMed ID: 20413648

Yao, X., Horie, T., Xue, S., Leung, H. Y., Katsuhara, M., Brodsky, D. E., Wu, Y. & Schroeder, J. I. Differential sodium and potassium transport selectivities of the rice OsHKT2;1 and OsHKT2;2 transporters in plant cells. Plant Physiol 152, 341-55 (2010). PMC2799368

PubMed ID: 19889878

Sadi, B. B., Vonderheide, A. P., Gong, J. M., Schroeder, J. I., Shann, J. R. & Caruso, J. A. An HPLC-ICP-MS technique for determination of cadmium-phytochelatins in genetically modified Arabidopsis thaliana. J Chromatogr B Analyt Technol Biomed Life Sci 861, 123-9 (2008). PMC2850270

PubMed ID: 18065298

Costa A, Drago I, Behera S, Zottini M, Pizzo P, Schroeder JI, Pozzan T, Schiavao FL. H(2)O(2) in plant peroxisomes: an in vivo analysis uncovers a Ca(2+)-dependent scavenging system. Plant J. 1; 62(5): 760-772, 2010. PMC2884081

PubMed ID: 20230493 | PubMed Central ID: PMC2884081 (Avail 6/1/11)

Kim TH, Bohmer M, Hu H, Nishimura N, Schroeder JI. Guard cell signal transduction network: advances in understanding Abscisic acid, CO2, and Ca2+ signaling. Annual Review of Plant Biology Epub Ahead of Print, 2010. PMC3056615

PubMed ID: 20192751

Nishimura N, Sarkeshik A, Nito K, Park SY, Wang A, Carvalho PC, Lee S, Caddell DF, Cutler SR, Chory J, Yates JR, Schroeder JI. PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J. 61: 290-299, 2010. PMC2807913

PubMed ID: 19874541 | PubMed Central ID: PMC2807913

Yao X, Horie T, Xue S, Leung HY, Katsuhara M, Brodsky DE, Wu Y, Schroeder JI. Differential sodium and potassium transport selectivities of the rice OsHKT2;1 and OsHKT2;2 transporters in plant cells. Plant Physiol. 152:341-355, 2010.

PubMed ID: 19889878 | PubMed Central ID: PMC2799368

Horie T, Hauser F, Schroeder JI. HKT transporter-mediated salinity resistance mechanisms in Arabidopsis and monocot crop plants. Trends Plant Sci. 14: 660-668, 2009. PMC2787891

PubMed ID: 19783197 | PubMed Central ID: PMC2787891

Ward JM, Mäser P, Schroeder JI. Plant ion channels: gene families, physiology, and functional genomics analyses. Annu Rev Physiol 71:59-82, 2009.

PubMed ID: 18842100

Sung DY, Kim TH, Komives EA, Mendoza-Cózatl DG, Schroeder JI. ARS5 is a component of the 26S proteasome complex, and negatively regulates thiol biosynthesis and arsenic tolerance in Arabidopsis. Plant J. 59(5):802-13, 2009. PMC2830867

PubMed ID: 19453443 | PubMed Central ID: NIHMSID 177191

Nishimura N, Hitomi K, Arvai AS, Rambo RP, Hitomi C, Cutler SR, Schroeder JI, Getzoff ED. Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science. 326(5958):1373-9. 2009. PMC2807913

PubMed ID: 19933100 | PubMed Central ID: NIHMSID 177184

Kim, Y.Y., Kim, D.Y., Shim, D., Song, W.Y., Lee, J., Schroeder, J.I., Kim, S., Moran, N., Lee Y. Expression of the Novel Wheat Gene TM20 Confers Enhanced Cadmium Tolerance to Bakers Yeast.JBiolChem.283:15893-15892(2008). PMC2414300

PubMed ID: 18411273 | PubMed Central ID: PMC2414300

Mendoza-Cozatl DG, Butko E, Springer F, Torpey JW, Komives EA, Kehr J, Schroeder JI. Identification of high levels of phytochelatins, glutathione and cadmium in the phloem sap of Brassica napus. A role for thiol-peptides in the long-distance transport of cadmium and the effect of cadmium on iron translocation. Plant Journal 54: 249-59, 2008. PMC2839885

PubMed ID: 18208526

Vahisalu, T., Kollist, H., Wang, Y.‐F., Nishimura, N., Chan, W.‐Y., Valerio, G., Lamminmaki, A., Brosche, M., Moldau, H., Desikan, R., Schroeder, J.I., Kangasjarvi, J. SLAC1 is required for plant guard cell S‐type anion channel function in
stomatal signalling. Nature 452:487‐91 (2008). PMC2858982

PubMed ID: 18305484

Horie T, Sugawara M, Okunou K, Nakayama H, Schroeder JI, Shinmyo A, Yoshida K. Functions of HKT transporters in sodium transport in roots and in protecting leaves from salinity stress. Plant Biotechnology 25: 233-239, 2008.

PubMed ID: Link to Pub

Horie, T., Costa, A., Kim, TH, Han, MH, Horie, R., Leung, HY, Miyao, A., Hirochika, H., An, G. and Schroeder, J.I. Rice OsHKT2;1 transporter mediates large Na+ influx component into K+-starved roots for growth. EMBO J. 26: 3003-3014, 2007.

PubMed ID: 17541409 | PubMed Central ID: PMC1894770

Sung DY, Lee D, Harris H, Raab A, Feldmann J, Meharg A, Kumabe B, Komives EA, Schroeder JI. Identification of an arsenic tolerant double mutant with a thiol-mediated component and increased arsenic tolerance in phyA mutants. Plant J. 49:1064-1075, 2007.

PubMed ID: 17335514

Imaizumi T, Kay SA, Schroeder JI. Circadian rhythms. Daily watch on metabolism. Science: 318: 1730-1731, 2007.

PubMed ID: 18006706

Imaizumi T, Schroeder JI, Kay SA. In SYNC: the ins and outs of circadian oscillations in calcium. Sci STKE: 390: pe32, 2007.

PubMed ID: 17565121

Chen A, Komives EA, Schroeder JI. An improved grafting technique for mature Arabidopsis plants demonstrates long-distance shoot-to-root transport of phytochelatins in Arabidopsis. Plant Physiology 141: 108-120, 2006.

PubMed ID: 16531489 | PubMed Central ID: PMC1459314

Kwak JM, Nguyen V, Schroeder JI. The role of reactive oxygen species in hormonal responses. Plant Physiology 141: 323-329, 2006.

PubMed ID: 16760482 | PubMed Central ID: PMC1475468

Platten JD, Cotsaftis O, Berthomieu P, Bohnert H, Davenport RJ, Fairbairn DJ, Horie T, Leigh RA, Lin HX, Luan S, Maser P, Pantoja O, Rodriguez-Navarro A, Schachtman DP, Schroeder JI, Sentenac H, Uozumi N, Very AA, Zhu JK, Dennis ES, Tester M. Nomenclature for HKT transporters, key determinants of plant salinity tolerance. Trends Plant Sci. 11: 372-374, 2006.

PubMed ID: 16809061

Schroeder JI, Nambara E. A quick release mechanism for abscisic acid. Cell 126: 1023-1025, 2006.

PubMed ID: 16990126

Schroeder JI, Kuhn JM. Plant biology abscisic acid in bloom. Nature 439: 277-278, 2006.

PubMed ID: 16421556

Sunarpi, Horie T, Motoda J, Kubo M, Yang H, Yoda K, Horie R, Chan W, Leung H-Y, Hattori K, Konomi M, Osumi M, Yamagami M, *Schroeder JI, *Uozumi N. (* corresponding authors) Enhanced salt tolerance mediated by AtHKT1 transporter-induced Na+ unloading from xylem parenchyma cells. Pl. Journal 44: 928-938, 2005.

PubMed ID: 16359386

Gong JM, Waner DA, Horie T, Li SL, Horie R, Abid KB, Schroeder JI. Microarray-based rapid cloning of an ion accumulation deletion mutant in Arabidopsis thaliana. Proc. Natl. Acad. Sci (USA) 101: 15404-15409, 2004.

PubMed ID: 15486089 | PubMed Central ID: PMC524449

Li Y, Dhankher OP, Carreira L, Lee D, Chen A, Schroeder JI, Balish RS, Meagher RB. Overexpression of phytochelatin synthase in Arabidopsis leads to enhanced arsenic tolerance and cadmium hypersensitivity. Plant Cell Physiol. 45: 1787-1797, 2004.

PubMed ID: 15653797

Mori I and Schroeder JI. Reactive Oxygen Species Activation of Plant Ca2+ Channels: A Signaling Mechanism in Polar Growth, Hormone Transduction, Stress Signaling, and Hypothetically Mechano-transduction. Plant Physiology 135(2): 702-708, 2004.

PubMed ID: 15208417 | PubMed Central ID: PMC514107

Wycisk K, Kim EJ, Schroeder JI, Kramer U. Enhancing the First Enzymatic Step in Histidine Biosynthesis Pathway Increases the Free Histidine Pool and Nickel Tolerance in Arabidosis Thaliana. FEBS Letters 578: 128-134, 2004.

PubMed ID: 15581629

Project 8: Anderson CR, Dick GJ, Chu ML, Bräuer S, Cho JC, Tebo BM. Aurantimonas manganoxydans, sp. nov. and Aurantimonas litoralis, sp. nov.: Mn(II) Oxidizing Representatives of a Globally Distributed Clade of apha-Proteobacteria from the Order Rhizobiales. Geomicrobiology Journal 26:189-198, 2009. PMC2746641; PubMed ID: 19768133 | PubMed Central ID: PMC2746641; Anderson CR, Johnson HA, Caputo N, Davis RE, Torpey JW, Tebo BM. Mn(II) oxidation is catalyzed by heme peroxidases in “Aurantimonas manganoxydans” strain SI85-9A1 and Erythrobacter sp. strain SD-21. Appl Environ Microbiol 75(12):4130-4138, 2009. PMC2698374; PubMed ID: 19411418 | PubMed Central ID: PMC2698374; Dick GJ, Podell S, Johnson HA, Bernier-Latmani R, McCarthy JK, Rivera Espinosa Y, Clement BG, Torpey JW, Gaasterland T, and Tebo BM. Genomic insights into Mn(II) oxidation by Aurantimonas sp. strain SI85-9A1, a globally distributed marine Mn(II)-oxidizing alpha-proteobacterium. Applied and Environmental Microbiology 74(9):2646-58, 2008. PMC2394881; PubMed ID: 18344346 | PubMed Central ID: PMC2394881; Dick GJ, Torepy JW, Beveridge TJ and Tebo BM. Direct identification of a bacterial manganese(II) oxidase: The multicopper oxidase MnxG. Applied and Environmental Microbiology 74(5):1527-34,2008. PMC2258647; PubMed ID: 18165363 | PubMed Central ID: PMC2258647; Johnson, H.A. and B.M. Tebo (2008). In vitro studies indicate the bacterial Mn(II)-oxidizing protein is a quinoprotein. Archives of Microbiology 189:59-69. PMC2721854; PubMed ID: 17673976 | PubMed Central ID: PMC2721854; Bencheikh-Latmani R, Obraztsova A, Mackey M, Ellisman M, and Tebo BM. Toxicity of Cr (III) to Shewanella sp. Strain MR-4 during Cr(VI) reduction. Environmental Science & Technology 41(1):214-220, 2007.; PubMed ID: 17265950; Murray KJ and Tebo BM. Cr(III) is indirectly oxidized by the Mn(II)-oxidizing bacterium Bacillus sp. strain SG-1. Environmental Science & Technology 41:528-533, 2007; PubMed ID: 17310717; Dick GJ, Lee YE, Tebo BM. Manganese(II)-oxidizing Bacillus spores in Guaymas Basin hydrothermal sediments and plumes. Appl Environ Microbiol 72(5):3184-90, 2006. PMC1472353; PubMed ID: 16672456 | PubMed Central ID: PMC1472353; Bencheikh-Latmani R, Williams SM, Haucke L, Criddle CS, Wu L, Zhou J, Tebo BM. Global transcriptional profiling of Shewanella oneidensis MR-1 during Cr(VI) and U(VI) reduction. Applied and Environmental Microbiology 71: 7453-7460, 2005. PMC1287662; PubMed ID: 16269787 | PubMed Central ID: PMC1287662; Tebo BM, Johnson HA, McCarthy JK, Templeton AS. Geomicrobiology of manganese(II) oxidation. Trends in Microbiology 13: 421-428, 2005.; PubMed ID: 16054815

Tools and Resources: currently no publications

Mouse Genetics Core: currently no publications

Protein Characterization Core: currently no publications

Molecular Imaging Core: Perkins GA, Sun MG, Frey TG. Correlated light and electron microscopy/electron tomography of mitochondria in situ. Methods Enzymol. 456:29-52, 2009.; PubMed ID: 19348881 | PubMed Central ID: PMC2730195; Yamaguchi R, Perkins G. Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1. Biochem Biophys Acta. 1787:963-972, 2009.; PubMed ID: 19245786 | PubMed Central ID: PMC2773558; Perkins G, Bossy-Wetzel E, and Ellisman MH. New insights into mitochondrial structure during cell death. Exp Neurol, 218:183-192, 2009.; PubMed ID: 19464290 | PubMed Central ID: PMC2712651; Knott, A.B., Perkins, G., Schwarzenbacher, R. and Bossy-Wetzel, E. Break Up: Mitochondrial Fragmentation In Neurodegeneration. Nature Reviews Neuroscience, 9:505-518, 2008.; PubMed ID: 18568013 | PubMed Central ID: PMC2711514; Yamaguchi R, Lartigue L, Perkins G, Scott RT, Dixit A, Kushnareva Y, Kuwana T, Ellisman MH, Newmeyer DD. Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Mol Cell. 2008 Aug 22;31(4):557-69. Epub 2008 Aug 7.; PubMed ID: 18691924 | PubMed Central ID: PMC2636708

Administration Core: currently no publications

Research Translation Core: Pezzoli K, Tukey R, Sarabia H, Zaslavsky I, Miranda ML, Suk WA, Lin A and Ellisman M. In Press. The NIEHS Environmental Health Sciences Data Resource Portal: Placing Advanced Technologies in Service to Vulnerable Communities. Environmental Health Perspectives 115(4):564-71, 2007.; PubMed ID: 17450225 | PubMed Central ID: PMC1852670

Community Outreach Core: Sarabia, H. 2008. “Toxics in Tijuana’s Laureles Canyon: Irregular Settlements, Human Health and Ecosystem Integrity” GPEIG:Newsletter of the Global Planning Educators Interest Group. Summer 2008. pp. 15-16; PubMed ID: http://www.gpeig.org/index.php/resources/newsletters; Sarabia, H. 2008. “Indigenous People and Toxics in the U.S.-Mexico Border and Latin America” GPEIG:Newsletter of the Global Planning Educators Interest Group. Summer 2008. pp. 13-14; PubMed ID: http://www.gpeig.org/index.php/resources/newsletters

Training Core: currently no publications