Project 8
Molecular Mechanisms of Bacterial Metal Redox Transformations
Dr. Brad Tebo
The primary objective of this project is to study the mechanisms of transformation and the fate of toxic substances in coastal environments. The molecular mechanisms by which metal contaminants are transformed from soluble phases to insoluble phases will be examined and the contribution from different physiological groups of bacteria to this process will be evaluated. Experiments will focus on the expression of genes and the characterization of multicopper oxidase-like proteins involved in catalyzing Mn(II) oxidation in different bacterial groups. In addition, project investigators have identified several novel bacteria that resist the toxic levels of Cr(VI) and grow with Cr(VI) as an electron acceptor. The second part of this project will examine the biochemical basis for Cr(VI) reduction in these novel Cr(VI)-reducing bacteria and study the regulation of Cr(VI) reduction and the expression of other genes in response to Cr(VI).
Recent Publications and Documents
Anderson CR, Dick GJ, Chu ML, Bräuer S, Cho JC, Tebo BM. Aurantimonas manganoxydans, sp. nov. and Aurantimonas litoralis, sp. nov.: Mn(II) Oxidizing Representatives of a Globally Distributed Clade of apha-Proteobacteria from the Order Rhizobiales. Geomicrobiology Journal 26:189-198, 2009. PMC2746641
PubMed ID: 19768133
Anderson CR, Johnson HA, Caputo N, Davis RE, Torpey JW, Tebo BM. Mn(II) oxidation is catalyzed by heme peroxidases in “Aurantimonas manganoxydans” strain SI85-9A1 and Erythrobacter sp. strain SD-21. Appl Environ Microbiol 75(12):4130-4138, 2009. PMC2698374
PubMed ID: 19411418
Dick GJ, Podell S, Johnson HA, Bernier-Latmani R, McCarthy JK, Rivera Espinosa Y, Clement BG, Torpey JW, Gaasterland T, and Tebo BM. Genomic insights into Mn(II) oxidation by Aurantimonas sp. strain SI85-9A1, a globally distributed marine Mn(II)-oxidizing alpha-proteobacterium. Applied and Environmental Microbiology 74(9):2646-58, 2008. PMC2394881
PubMed ID: 18344346
Dick GJ, Torepy JW, Beveridge TJ and Tebo BM. Direct identification of a bacterial manganese(II) oxidase: The multicopper oxidase MnxG. Applied and Environmental Microbiology 74(5):1527-34,2008. PMC2258647
PubMed ID: 18165363
Johnson, H.A. and B.M. Tebo (2008). In vitro studies indicate the bacterial Mn(II)-oxidizing protein is a quinoprotein. Archives of Microbiology 189:59-69. PMC2721854
PubMed ID: 17673976
Bencheikh-Latmani R, Obraztsova A, Mackey M, Ellisman M, and Tebo BM. Toxicity of Cr (III) to Shewanella sp. Strain MR-4 during Cr(VI) reduction. Environmental Science & Technology 41(1):214-220, 2007.
PubMed ID: 17265950
Murray KJ and Tebo BM. Cr(III) is indirectly oxidized by the Mn(II)-oxidizing bacterium Bacillus sp. strain SG-1. Environmental Science & Technology 41:528-533, 2007
PubMed ID: 17310717
Dick GJ, Lee YE, Tebo BM. Manganese(II)-oxidizing Bacillus spores in Guaymas Basin hydrothermal sediments and plumes. Appl Environ Microbiol 72(5):3184-90, 2006. PMC1472353
PubMed ID: 16672456
Bencheikh-Latmani R, Williams SM, Haucke L, Criddle CS, Wu L, Zhou J, Tebo BM. Global transcriptional profiling of Shewanella oneidensis MR-1 during Cr(VI) and U(VI) reduction. Applied and Environmental Microbiology 71: 7453-7460, 2005. PMC1287662
PubMed ID: 16269787
Tebo BM, Johnson HA, McCarthy JK, Templeton AS. Geomicrobiology of manganese(II) oxidation. Trends in Microbiology 13: 421-428, 2005.
PubMed ID: 16054815
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