Publication Highlight: FXR Regulates Intestinal Cancer Stem Cell Proliferation

Posted on February 21, 2019 by MFeiock


Scientists uncover how high-fat diet drives colorectal cancer growth

Experimental drug candidate slows cancer progression in mouse model

A new study led by Salk Institute scientists suggests that high-fat diets fuel colorectal cancer growth by upsetting the balance of bile acids in the intestine and triggering a hormonal signal that lets potentially cancerous cells thrive. The findings, which appeared in Cell on February 21, 2019, could explain why colorectal cancer, which can take decades to develop, is being seen in younger people growing up at a time when higher-fat diets are common.

"This study provides a new way to lower inflammation, restore intestinal health and to dramatically reduced tumor progression," says Professor Ronald Evans, director of the Gene Expression Laboratory, Howard Hughes Medical Institute investigator and holder of Salk's March of Dimes Chair in Molecular and Developmental Biology.  Dr. Evans is also the Project Leader of Project 2 for the UCSD Superfund Research Center in which this study was partially funded.

To read more about this research, please visit the study where it is published online in Cell  (February 21, 2019).

Original Source: The Salk Institute of Biological Studies - News Release

Farnesoid X receptor (FXR): (FXR) is a nuclear bile acid receptor that regulates the expression of bile acid transporters, such as Abcb11/bile salt export pump (Bsep).

Published study:

Ting Fu, Sally Coulter, Eiji Yoshihara, Tae Gyu Oh, Sungsoon Fang, Fritz Cayabyab, Qiyun Zhu, Tong Zhang, Mathias Leblanc, Sihao Liu, Mingxiao He, Wanda Waizenegger, Emanuel Gasser, Bernd Schnabl, Annette R. Atkins, Ruth T. Yu, Rob Knight, Christopher Liddle, Michael Downes, Ronald M. Evans. FXR Regulates Intestinal Cancer Stem Cell Proliferation. Cell, 2019; 176 (5): 1098. doi: 10.1016/j.cell.2019.01.036 |  PMID: PENDING  PMCID: PENDING

For more information, please visit the following UCSD Superfund Research Project:

UCSD Superfund Research Center - Project 2: Dr. Ronald M. Evans

The Salk Institute of Biological Studies
Dr. Ronald M. Evans
SALK Institute for Biological StudiesGene Expression Laboratory
10010 North Torrey Pines Road
La Jolla, CA 92037


UCSD Superfund Research Center
University of California, San Diego
Pharmacology Department
9500 Gilman Drive, Mail Code 0722
La Jolla, CA 92093-0722