Baglieri J, Brenner DA, Kisseleva T. (2019) The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Int J Mol Sci. Apr 7; 20(7). pii: E1723. Review. doi: 10.3390/ijms20071723
Mills, P.J., Caussy, C., Loomba, R. (2019) Glyphosate Excretion is Associated With Steatohepatitis and Advanced Liver Fibrosis in Patients With Fatty Liver Disease. Clin Gastroenterol Hepatol. pii: S1542-3565(19)30361-1. doi: 10.1016/j.cgh.2019.03.045. (https://www.sciencedirect.com/science/article/abs/pii/S1542356519303611?...) [Epub ahead of print]
Caussy, C., Tripathi, A., Humphrey, G., Bassirian, S., Singh, S., Faulkner, C., Bettencourt, R., Rizo, E., Richards, L., Xu, Z.Z., Downes, M.R., Evans, R.M., Brenner, D.A., Sirlin, C.B., Knight, R., Loomba, R. (2019) A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Nat Commun. Mar 29; 10(1):1406. doi: 10.1038/s41467-019-09455-9
Tonsfeldt, K.J., Schoeller, E.L., Brusman, L.E., Cui, L.J., Lee, J., Mellon, P.L. (2019) The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge. J Endocr Soc. 3(4):716-733. doi: 10.1210/js.2018-00228. (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30906911/) eCollection 2019 Apr 1.
Caussy, C., Bhargava, M., Villesen, I.F., Gudmann, N.S., Leeming, D.J., Karsdal, M.A., Faulkner, C., Bao, D., Liu ,A., Lo, M.T., Bettencourt, R., Bassirian, S., Richards, L., Brenner, D.A., Chen, C.H., Sirlin, C.B., Loomba, R. (2019) Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Hepatology. 70(1):127-141. doi: 10.1002/hep.30610. (https://doi.org/10.1002/hep.30610) Epub 2019 Apr 29.
Fu, T., Coulter, S., Yoshihara, E., Oh, T.G., Fang, S., Cayabyab, F., Zhu, Q., Zhang, T., Leblanc, M., Liu, S., He, M., Waizenegger, W., Gasser, E., Schnabl, B., Atkins, A.R., Yu, R.T., Knight, R., Liddle, C., Downes, M., Evans, R.M. (2019) FXR Regulates Intestinal Cancer Stem Cell Proliferation. Cell. 176(5):1098-1112.e18. doi: 10.1016/j.cell.2019.01.036.
Hoffmann, H.M., Larder, R., Lee, J.S., Hu, R.J., Trang, C., Devries, B.M., Clark, D.D., Mellon, P.L. (2019) Differential CRE Expression in Lhrh-cre and GnRH-cre Alleles and the Impact on Fertility in Otx2-Flox Mice. Neuroendocrinology. 108(4):328-342. doi: 10.1159/000497791. Epub 2019 Feb 10.
Karin M. New insights into the pathogenesis and treatment of non-viral hepatocellular carcinoma: a balancing act between immunosuppression and immunosurveillance. (2018) Precis Clin Med. 1(1):21-28. doi: 10.1093/pcmedi/pby005. Epub 2018 Jun 4. Review.
Castera, L., Friedrich-Rust, M., Loomba, R. (2019) Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 156(5):1264-1281.e4. doi: 10.1053/j.gastro.2018.12.036. Epub 2019 Jan 18. Review.
Park, J., Kim, T.H., Takahashi, Y., Schwab, R., Dressano, K., Stephan, A.B., Ceciliato, P.H.O., Ramirez, E., Garin, V., Huffaker, A., Schroeder, J.I. (2019) Chemical genetic identification of a lectin receptor kinase that transduces immune responses and interferes with abscisic acid signaling. Plant J. 98(3):492-510. Epub 2019 Mar 7. doi:10.1111/tpj.14232
Febbraio, M.A., Reibe, S., Shalapour, S., Ooi, G.J., Watt, M.J., Karin, M.. (2019) Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? Cell Metab. 29(1):18-26. doi: 10.1016/j.cmet.2018.10.012. Epub 2018 Nov 15. Review.
Liang, S., Ma, H.Y., Zhong, Z., Dhar, D., Liu, X., Xu, J., Koyama, Y., Nishio, T., Karin, D., Karin, G., Mccubbin, R., Zhang, C., Hu, R., Yang, G., Chen, L., Ganguly, S., Lan, T., Karin, M., Kisseleva, T., Brenner, D.A. (2018) NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 156(4):1156-1172.e6. doi: 10.1053/j.gastro.2018.11.019. Epub 2018 Nov 13.
Hauser, F., Ceciliato, P.H.O., Lin, Y.C., Guo, D., Gregerson, J.D., Abbasi, N., Youhanna, D., Park, J., Dubeaux, G., Shani, E., Poomchongkho, N., Schroeder, J.I. (2019) A seed resource for screening functionally redundant genes and isolation of new mutants impaired in CO2 and ABA responses. J Exp Bot. 70(2):641-651. doi: 10.1093/jxb/ery363
Zhang, Y., Nasser, V., Pisanty, O., Omary, M., Wulff, N., Di, Donato, M., Tal, I., Hauser, F., Hao, P., Roth, O., Fromm, H., Schroeder, J.I., Geisler, M., Nour-Eldin, H.H., Shani, E. (2018) A transportome-scale amiRNA-based screen identifies redundant roles of Arabidopsis ABCB6 and ABCB20 in auxin transport. Nat Commun. 9(1):4204.
doi: 10.1038/s41467-018-06410-y
Dow, M., Pyke, R.M., Tsui, B.Y., Alexandrov, L.B., Nakagawa, H., Taniguchi, K., Seki, E., Harismendy, O., Shalapour, S., Karin, M., Carter, H., Font-Burgada, J. (2018) Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 115(42):E9879-E9888. doi: 10.1073/pnas.1811029115. Epub 2018 Oct 4.
Hsu, P.K., Takahashi, Y., Munemasa, S., Merilo, E., Laanemets, K., Waadt, R., Pater, D., Kollist, H., Schroeder, J.I. (2018) Abscisic acid-independent stomatal CO2 signal transduction pathway and convergence of CO2 and ABA signaling downstream of OST1 kinase. Proc Natl Acad Sci U S A. 115(42):E9971-E9980. Epub 2018 Oct 3.
doi: 10.1073/pnas.1809204115
Hoffmann, H.M., Pandolfi, E.C., Larder, R., Mellon, P.L.. (2019) Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2 Causes Subfertility in Mice via Distinct Mechanisms. Neuroendocrinology. 109(3):200-207. doi: 10.1159/000494086. Epub 2018 Sep 27. Review.
Kim, J.Y., Garcia-Carbonell, R., Yamachika, S., Zhao, P., Dhar, D., Loomba, R., Kaufman, R.J., Saltiel, A.R., Karin, M. (2018) ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. 175(1):133-145.e15. doi: 10.1016/j.cell.2018.08.020. Epub 2018 Sep 13.
Tõldsepp, K., Zhang, J., Takahashi, Y., Sindarovska, Y., Hõrak, H., Ceciliato, P.H.O., Koolmeister, K., Wang, Y.S., Vaahtera, L., Jakobson, L., Yeh, C.Y., Park, J., Brosche, M., Kollist, H., Schroeder, J.I. (2018) Mitogen-activated protein kinases MPK4 and MPK12 are key components mediating CO2 -induced stomatal movements. Plant J. 96(5):1018-1035. Epub 2018 Oct 23. doi: 10.1111/tpj.14087
Chen, S., Tukey, R.H. (2018) Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice. Drug Metab Dispos. 46(11):1745-1755.
doi: 10.1124/dmd.118.083212. Epub 2018 Aug 9.
Zhong, Z., Liang, S., Sanchez-Lopez, E., He, F., Shalapour, S., Lin, X.J., Wong, J., Ding, S., Seki, E., Schnabl, B., Hevener, A.L., Greenberg, H.B., Kisseleva, T., Karin, M. (2018) New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 560(7717):198-203. doi: 10.1038/s41586-018-0372-z. Epub 2018 Jul 25.
Brenner, D.A. (2018) Of Mice and Men and Nonalcoholic Steatohepatits. Hepatology. 68(6):2059-2061. doi: 10.1002/hep.30186. Epub 2018 Nov 13. No abstract available.
Roh, Y.S., Seki, E. (2018) Chemokines and Chemokine Receptors in the Development of NAFLD. Adv Exp Med Biol.1061:45-53. doi: 10.1007/978-987-10-8684-7_4. Review
Dhar, D., Antonucci, L., Nakagawa, H., Kim, J.Y., Glitzner, E., Caruso, S., Shalapour, S., Yang, L., Valasek, M.A., Lee, S., Minnich, K., Seki, E., Tuckermann, J., Sibilia, M., Zucman-Rossi, J., Karin, M. (2018) Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 33(6):1061-1077.e6. doi: 10.1016/j.ccell.2018.05.003.
Que, X., Hung, M.Y., Yeang, C., Gonen, A., Prohaska, T.A., Sun, X., Diehl, C., Määttä, A., Gaddis, D.E., Bowden, K., Pattison, J., MacDonald, J.G., Ylä-Herttuala, S., Mellon, P.L., Hedrick, C.C., Ley, K., Miller, Y.I., Glass, C.K., Peterson, K.L., Binder, C.J., Tsimikas, S., Witztum, J.L. (2018) Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 558(7709):301-306. doi: 10.1038/s41586-018-0198-8. Epub 2018 Jun 6.
Tripathi, A., Debelius, J., Brenner, D.A., Karin, M., Loomba, R., Schnabl, B., Knight, R. (2018) The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 15(12):785. doi: 10.1038/s41575-018-0031-8.
Wei, Z., Yoshihara, E., He, N., Hah, N., Fan, W., Pinto, A.F.M., Huddy, T., Wang, Y., Ross, B., Estepa, G., Dai, Y., Ding, N., Sherman, M.H., Fang, S., Zhao, X., Liddle, C., Atkins, A.R., Yu, R.T., Downes, M., Evans, R.M. (2018) Vitamin D Switches BAF Complexes to Protect β Cells. Cell. 173(5):1135-1149.e15. doi: 10.1016/j.cell.2018.04.013. Epub 2018 May 10.
Li, Z., Takahashi, Y., Scavo, A., Brandt, B., Nguyen, D., Rieu, P., Schroeder, J.I. (2018) Abscisic acid-induced degradation of Arabidopsis guanine nucleotide exchange factor requires calcium-dependent protein kinases. Proc Natl Acad Sci U S A. 115(19):E4522-E4531. Epub 2018 Apr 23. doi: 10.1073/pnas.1719659115
Ajmera, V., Park, C.C., Caussy, C., Singh, S., Hernandez, C., Bettencourt, R., Hooker, J., Sy, E., Behling, C., Xu, R., Middleton, M.S., Valasek, M.A., Faulkner, C., Rizo, E., Richards, L., Sirlin, C.B., Loomba, R. (2018) Magnetic Resonance Imaging Proton Density Fat Fraction Associates With Progression of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 155(2):307-310.e2. doi: 10.1053/j.gastro.2018.04.014. Epub 2018 Apr 13.
McNulty, R., Cardone, G., Gilcrease, E.B., Baker, T.S., Casjens, S.R., Johnson, J.E. (2018) Cryo-EM Elucidation of the Structure of Bacteriophage P22 Virions after Genome Release. Biophys J. 114(6):1295-1301. doi: 10.1016/j.bpj.2018.01.026.
Pandolfi, E.C., Hoffmann, H.M., Schoeller, E.L., Gorman, M.R., Mellon, P.L. (2018) Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration. Mol Neurobiol. 55(11):8709-8727. doi: 10.1007/s12035-018-1013-0. Epub 2018 Mar 27.
Caussy, C., Hsu, C., Lo, M.T., Liu, A., Bettencourt, R., Ajmera, V.H., Bassirian, S., Hooker, J., Sy, E., Richards, L., Schork, N., Schnabl, B., Brenner, D.A., Sirlin, C.B., Chen, C.H., Loomba, R.; Genetics of NAFLD in Twins Consortium. (2018) Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Hepatology. doi: 10.1002/hep.29892.
Ahmadian, M., Liu, S., Reilly, S.M., Hah, N., Fan, W., Yoshihara, E., Jha, P., De Magalhaes Filho, C.D., Jacinto, S., Gomez, A.V., Dai, Y., Yu, R.T., Liddle, C., Atkins, A.R., Auwerx, J., Saltiel, A.R., Downes, M., Evans, R.M. (2018) ERRγ Preserves Brown Fat Innate Thermogenic Activity. Cell Rep. 22(11):2849-2859. doi: 10.1016/j.celrep.2018.02.061.
Fan, W., He, N., Lin, C.S., Wei Z., Hah, N., Waizenegger, W., He, M.X., Liddle, C., Yu, R.T., Atkins, A.R., Downes, M., Evans, R.M. (2018) ERRγ Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1α/β-Deficient Muscle. Cell Rep. 22(10):2521-2529. doi: 10.1016/j.celrep.2018.02.047.
Desai, A.P., Mohan, P., Roubal, A.M., Bettencourt, R., Loomba, R. (2018) Geographic Variability in Liver Disease-Related Mortality Rates in the United States. Am J Med. 131(7):728-734. doi: 10.1016/j.amjmed.2018.01.047. Epub 2018 Feb 26.
Xu J., Ma H.Y., Liang S., Sun M., Karin G., Koyama Y., Hu R., Quehenberger O., Davidson N.O., Dennis E.A., Kisseleva T., Brenner D.A. (2017) The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Hepatol Commun. 1(10):1043-1057. doi: 10.1002/hep4.1115. eCollection 2017 Dec.
Fujiwara R., Mitsugi R., Uemura A., Itoh T., Tukey R.H. (2017) Severe Neonatal Hyperbilirubinemia in Crigler-Najjar Syndrome Model Mice Can Be Reversed With Zinc Protoporphyrin. Hepatol Commun. 1(8):792-802. doi: 10.1002/hep4.1082. Epub 2017 Aug 10.
Song, N.Y., Zhu, F., Wang, Z., Willette-Brown, J., Xi, S., Sun, Z., Su, L., Wu, X., Ma, B., Nussinov, R., Xia, X., Schrump, D.S., Johnson, P.F., Karin, M., Hu, Y. (2018) IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proc Natl Acad Sci U S A. 115(4):E812-E821. doi: 10.1073/pnas.1717520115. Epub 2018 Jan 8.
Tapper, E.B., Loomba, R. (2018) Nonalcoholic fatty liver disease, metabolic syndrome, and the fight that will define clinical practice for a generation of hepatologists. Hepatology. 67(5):1657-1659. doi: 10.1002/hep.29722. Epub 2018 Apr 1.
Dickey A.S., Sanchez D.N., Arreola M., Sampat K.R., Fan W., Arbez N., Akimov S., Van Kanegan M.J., Ohnishi K., Gilmore-Hall S.K., Flores A.L., Nguyen J.M., Lomas N., Hsu C.L., Lo D.C., Ross C.A., Masliah E., Evans R.M., La Spada A.R. PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis. (2017) Sci Transl Med. 9(419). pii: eaal2332. doi: 10.1126/scitranslmed.aal2332.
Hartmann P., Hochrath K., Horvath A., Chen P., Seebauer C.T., Llorente C., Wang L., Alnouti Y., Fouts D.E., Stärkel P., Loomba R., Coulter S., Liddle C., Yu R.T., Ling L., Rossi S.J., DePaoli A.M., Downes M., Evans R.M., Brenner D.A., Schnabl B. (2017) Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice. Hepatology. doi: 10.1002/hep.29676.
Shalapour, S., Lin, X.J., Bastian, I.N., Brain, J., Burt, A.D., Aksenov, A.A., Vrbanac, A.F., Li, W., Perkins, A., Matsutani, T., Zhong, Z., Dhar, D., Navas-Molina, J.A., Xu, J., Loomba, R., Downes, M., Yu, R.T., Evans, R.M., Dorrestein, P.C., Knight, R., Benner, C., Anstee, Q.M., Karin, M. (2017). Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 551, 340-345. doi: 10.1038/nature24302.
Cao Q., Zhao X., Bai J., Gery S., Sun H., Lin D.C., Chen Q., Chen Z., Mack L., Yang H., Deng R., Shi X., Chong L.W., Cho H., Xie J., Li Q.Z., Müschen M., Atkins A.R., Liddle C., Yu R.T., Alkan S., Said J.W., Zheng Y., Downes M., Evans R.M., Koeffler H.P. (2017) Circadian clock cryptochrome proteins regulate autoimmunity. Proc Natl Acad Sci U S A. 114(47):12548-12553. doi: 10.1073/pnas.1619119114.