He F, Antonucci L, Karin M. NRF2 as a regulator of cell metabolism and inflammation in cancer. Carcinogenesis. 2020 Jun 17;41(4):405-416. doi: 10.1093/carcin/bgaa039.
He F, Antonucci L, Yamachika S, Zhang Z, Taniguchi K, Umemura A, Hatzivassiliou G, Roose-Girma M, Reina-Campos M, Molina AD, Diaz-Meco MT, Moscat J, Sun B, Karin M. (2020) NRF2 Activates Growth Factor Genes and Downstream AKT Signaling to Induce Mouse and Human Hepatomegaly. Journal of Hepatology, Accepted.
doi: 10.1016/j.jhep.2020.01.023
Quinn R.A., Melnik A.V., Vrbanac A., Fu T., Patras K.A., Christy M.P., Bodai Z., Belda-Ferre P., Tripathi A., Chung L.K., Downes M., Welch R.D., Quinn M., Humphrey G., Panitchpakdi M., Weldon K.C., Aksenov A., da Silva R., Avila-Pacheco J., Clish C., Bae S., Mallick H., Franzosa E.A., Lloyd-Price J., Bussell R., Thron T., Nelson A.T., Wang M., Leszczynski E., Vargas F., Gauglitz J.M., Meehan M.J., Gentry E., Arthur T.D., Komor A.C., Poulsen O., Boland B.S., Chang J.T., Sandborn W.J., Lim M., Garg N., Lumeng J.C., Xavier R.J., Kazmierczak B.I., Jain R., Egan M., Rhee K.E., Ferguson D., Raffatellu M., Vlamakis H., Haddad G.G., Siegel D., Huttenhower C., Mazmanian S.K., Evans R.M., Nizet V., Knight R., Dorrestein P.C. (2020) Global chemical effects of the microbiome include new bile-acid conjugations. Nature 579, 123–129. doi: 10.1038/s41586-020-2047-9
Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 Feb 13;5(3):e131277. doi: 10.1172/jci.insight.131277.
Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, Singh S, Loomba, R, Karin M, Witztum JL, Saltiel AR. (2020) An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science. Feb 7; 367(6478):652-660.
doi: 10.1126/science.aay0542
Hansmann, E., Mennillo, E., Yoda, E., Verreault, M., Barbier, O., Chen, S.J., Tukey, R.H. (2020) Differential role of LXRa and LXRß in the regulation of UDP-glucuronosyltransferase 1A1 in humanized UGT1 mice. Drug Metab Dispos. Jan 24.
doi: 10.1124/dmd.119.090068
Dhar, D., Baglieri, J., Kisseleva, T. and Brenner, D.A. (2020) Mechanisms of liver fibrosis and its role in cancer. Exp Biol Med (Maywood). Jan 10:1535370219898141. doi: 10.1177/1535370219898141
Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. (2019) IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. Dec 31.
doi: 10.1016/j.jhep.2019.12.016
Takahashi, Y., Zhang, J., Hsu, P.K., Ceciliato, P.H.O., Zhang, L., Dubeaux, G., Munemasa, S., Ge, C., Zhao, Y., Hauser, F., Schroeder, J.I. (2020) MAP3Kinase-Dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response. Nat Commun. 2020 Jan 2;11(1):12. doi: 10.1038/s41467-019-13875-y
Sun, X., Seidman, J.S., Zhao, P., Troutman, T.D., Spann, N.J., Que, X., Zhou, F., Liao, Z., Pasillas, M., Yang, X., Magida, J.A., Kisseleva, T., Brenner, D.A.,Downes, M., Evans, R.M., Saltiel, A.R., Tsimikas, S., Glass, C.K., Witztum, J.L. (2020) Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metab. Jan 7;31(1):189-206.e8.
doi: 10.1016/j.cmet.2019.10.014
Pandolfi, E.C., Breuer, J.A., Nguyen Huu, V.A., Talluri, T., Nguyen, D., Lee, J.S., Hu, R., Bharti, K., Skowronska-Krawczyk, D., Gorman, M.R., Mellon, P.L., Hoffmann, H.M. (2019) The Homeodomain Transcription Factors Vax1 and Six6 Are Required for SCN Development and Function. Mol Neurobiol. doi: 10.1007/s12035-019-01781-9. (https://link.springer.com/article/10.1007%2Fs12035-019-01781-9) [Epub ahead of print]
Paszek, M., Tukey, R.H. (2020) NRF2-Independent Regulation of Intestinal Constitutive Androstane Receptor by the Pro-Oxidants Cadmium and Isothiocyanate in hUGT1 Mice. Drug Metab Dispos. Jan; 48(1):25-30.
doi: 10.1124/dmd.119.089508.
Bailey-Serres J, Parker JE, Ainsworth EA, Oldroyd GED, Schroeder JI. (2019) Genetic strategies for improving crop yields. Nature. Nov;575(7781):109-118. doi: 10.1038/s41586-019-1679-0
Cai, D., Wang, J., Gao, B., Li, J., Wu, F., Zou, J.X., Xu, J., Jiang, Y., Zou, H., Huang, Z., Borowsky, A.D., Bold, R.J., Lara, P.N., Li, J.J., Chen, X., Lam, K.S., To, K.F., Kung, H.J., Fiehn, O., Zhao, R., Evans, R.M., Chen, H.W. (2019) RORy is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat Commun. Oct 11;10(1):4621.
doi: 10.1038/s41467-019-12529-3
Pai, R.K., Kleiner, D.E., Hart, J., Adeyi, O.A., Clouston, A.D., Behling, C.A., Jain, D., Kakar, S., Brahmania, M., Burgart, L., Batts, K.P., Valasek, M.A., Torbenson, M.S., Guindi, M., Wang, H.L., Ajmera, V., Adams, L.A., Parker, C.E., Feagan, B.G., Loomba, R., Jairath, V. (2019) Standardising the interpretation of liver biopsies in non-alcoholic fatty liver disease clinical trials. Aliment Pharmacol Ther. 50(10):1100-1111. doi: 10.1111/apt.15503. (https://onlinelibrary.wiley.com/doi/full/10.1111/apt.15503) Epub 2019 Oct 3.
Ajmera VH, Liu A, Singh S, Yachoa G, Ramey M, Bhargava M, Zamani A, Lopez S, Mangla N, Bettencourt R, Rizo E, Valasek M, Behling C, Richards L, Sirlin C, Loomba R. (2019) Clinical utility of an increase in magnetic resonance elastography in predicting fibrosis progression in NAFLD. Hepatology. Sep 25. doi: 10.1002/hep.30974
Loomba, R., Adams, L.A. (2019) The 20% Rule of NASH Progression: The Natural History of Advanced Fibrosis and Cirrhosis Caused by NASH. Hepatology. Dec;70(6):1885-1888. doi: 10.1002/hep.30946
Chang, C., Loo, C.S., Zhao, X., Solt, L.A., Liang, Y., Bapat, S.P., Cho, H., Kamenecka, T.M., Leblanc, M., Atkins, A.R., Yu, R.T., Downes, M., Burris, T.P., Evans, R.M., Zheng, Y. (2019) The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease. Proc Natl Acad Sci U S A. Sep 10;116(37):18528-18536. doi: 10.1073/pnas.1907563116.