Superfund Publications

Search publications on site
PubMed Central ID: 

He N., Fan W., Henriquez B., Yu R.T., Atkins A.R., Liddle C., Zheng Y., Downes M., Evans R.M. (2017) Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. Proc Natl Acad Sci U S A. 114(47):12542-12547. doi: 10.1073/pnas.1715363114.

PubMedID: 29109251
PubMed Central ID: 

Fujiwara R., Yoda E., Tukey R.H. (2018) Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans. Drug Metab Pharmacokinet. 33(1):9-16. doi: 10.1016/j.dmpk.2017.10.002. Epub 2017 Oct 7.

PubMedID: 29079228
PubMed Central ID: 

Xie H., Hoffmann H.M., Iyer A.K., Brayman M.J., Ngo C., Sunshine M.J., Mellon P.L. (2017) Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. Reprod Biol Endocrinol. 15(1):86. doi: 10.1186/s12958-017-0304-z.

PubMedID: 29065928

Brouha, S.S., Nguyen, P., Bettencourt, R., Sirlin, C.B., Loomba, R. (2018) Increased severity of liver fat content and liver fibrosis in non-alcoholic fatty liver disease correlate with epicardial fat volume in type 2 diabetes: A prospective study. Eur Radiol. 28(4):1345-1355. doi: 10.1007/s00330-017-5075-6. Epub 2017 Oct 20.

PubMedID: 29058029
PubMed Central ID: 

Wang J., He N., Zhang N., Quan D., Zhang S., Zhang C., Yu R.T., Atkins A.R., Zhu R., Yang C., Cui Y., Liddle C., Downes M., Xiao H., Zheng Y., Auwerx J., Evans R.M., Leng Q. (2017) NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. Nat Commun. 8(1):959. doi: 10.1038/s41467-017-00931-8.

PubMedID: 29038463
PubMed Central ID: 

Azoulay-Shemer T, Hsu PK, Schroeder JI. (2017) Seeing is believing. Nat Plants. 3(10):765-766. doi: 10.1038/s41477-017-0025-5.

PubMedID: 28970562
PubMed Central ID: 

Hoffmann H.M., Gong P., Tamrazian A., Mellon P.L. (2018) Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol. 461:143-154. doi: 10.1016/j.mce.2017.09.004. Epub 2017 Sep 7.

PubMedID: 28890143
PubMed Central ID: 

Song IJ, Yang YM, Inokuchi-Shimizu S, Roh YS, Yang L, Seki E. (2018) The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice. Int J Cancer. 142(1):81-91. doi: 10.1002/ijc.31029. Epub 2017 Sep 23.

PubMedID: 28875549
PubMed Central ID: 

Caussy C., Soni M., Cui J., Bettencourt R., Schork N., Chen C.H., Ikhwan M.A., Bassirian S., Cepin S., Gonzalez M.P., Mendler M., Kono Y., Vodkin I., Mekeel K., Haldorson J., Hemming A., Andrews B., Salotti J., Richards L., Brenner D.A., Sirlin C.B., Loomba R., Familial NAFLD Cirrhosis Research Consortium. (2017) Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Invest. 127(7):2697-2704. doi: 10.1172/JCI93465. Epub 2017 Jun 19.

PubMedID: 28628033
PubMed Central ID: 

Vollmann E.H., Cao L., Amatucci A., Reynolds T., Hamann S., Dalkilic-Liddle I., Cameron T.O., Hossbach M., Kauffman K.J., Mir F.F., Anderson D.G., Novobrantseva T., Koteliansky V., Kisseleva T., Brenner D., Duffield J., Burkly L.C. (2017) Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing. Mol Ther Nucleic Acids. 7:314-323. doi: 10.1016/j.omtn.2017.04.014. Epub 2017 Apr 20.

PubMedID: 28624207
PubMed Central ID: 

Reinders M.E., Wardi G., Bettencourt R., Bouland D., Bazick J., Mendler M., Vodkin I., Kalmaz D., Savides T., Brenner D., Sell R.E., Loomba R. (2017) Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Clin Gastroenterol Hepatol. 15(11):1808-1810. doi: 10.1016/j.cgh.2017.05.044. Epub 2017 Jun 7.

PubMedID: 28602970
PubMed Central ID: 

Kim R.G., Loomba R., Prokop L.J., Singh S. (2017) Statin Use and Risk of Cirrhosis and Related Complications in Patients With Chronic Liver Diseases: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 15(10):1521-1530.e8. doi: 10.1016/j.cgh.2017.04.039. Epub 2017 May 4.

PubMedID: 28479502
PubMed Central ID: 

Fan W., Waizenegger W., Lin C.S., Sorrentino V., He M.X., Wall C.E., Li H., Liddle C., Yu R.T., Atkins A.R., Auwerx J., Downes M., Evans R.M. (2017) PPARδ Promotes Running Endurance by Preserving Glucose. Cell Metab. 25(5):1186-1193.e4. doi: 10.1016/j.cmet.2017.04.006.

PubMedID: 28467934
PubMed Central ID: 
Loomba, R., Seguritan, V., Li, W., Long, T., Klitgord, N., Bhatt, A., Dulai, P. S., Caussy, C., Bettencourt, R., Highlander, S. K., Jones, M. B., Sirlin, C. B., Schnabl, B., Brinkac, L., Schork, N., Chen, C. H., Brenner, D. A., Biggs, W., Yooseph, S., Venter, J. C., … Nelson, K. E. (2017). Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell metabolism, 25(5), 1054–1062.e5. https://doi.org/10.1016/j.cmet.2017.04.001
PubMedID: 28467925
PubMed Central ID: 

Loomba R., Seguritan V., Li W., Long T., Klitgord N., Bhatt A., Dulai P.S., Caussy C., Bettencourt R., Highlander S.K., Jones M.B., Sirlin C.B., Schnabl B., Brinkac L., Schork N., Chen C.H., Brenner D.A., Biggs W., Yooseph S., Venter J.C., Nelson K.E. (2017) Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metab. 25(5):1054-1062.e5. doi: 10.1016/j.cmet.2017.04.001.

PubMedID: 28467925
PubMed Central ID: 

Yoda E., Paszek M., Konopnicki C., Fujiwara R., Chen S., Tukey R.H. (2017) Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress. Sci Rep. 7:46489. doi: 10.1038/srep46489

PubMedID: 28422158
PubMed Central ID: 

Doktorova M., Zwarts I., Zutphen T.V., Dijk T.H., Bloks V.W., Harkema L., Bruin A., Downes M., Evans R.M., Verkade H.J., Jonker J.W. (2017) Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia. Sci Rep. 7(1):846. doi: 10.1038/s41598-017-00889-z.

PubMedID: 28404991
PubMed Central ID: 

Wu C.C., Baiga T.J., Downes M., La Clair J.J., Atkins A.R., Richard S.B., Fan W., Stockley-Noel T.A., Bowman M.E., Noel J.P., Evans R.M. (2017) Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ. 114(13):E2563-E2570. doi: 10.1073/pnas.1621513114.

PubMedID: 28320959
PubMed Central ID: 

Koyama Y., Wang P., Liang S., Iwaisako K., Liu X., Xu J., Zhang M., Sun M., Cong M., Karin D., Taura K., Benner C., Heinz S., Bera T., Brenner D.A., Kisseleva T. (2017) Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 127(4):1254-1270. doi: 10.1172/JCI88845. Epub 2017 Mar 13.

PubMedID: 28287406
PubMed Central ID: 

De Magalhaes Filho C.D., Downes M., Evans R.M. (2017) Farnesoid X Receptor an Emerging Target to Combat Obesity. Dig Dis. 35(3):185-190. doi: 10.1159/000450909.

PubMedID: 28249279
PubMed Central ID: 

Seki E. (2016) Acrolein, a New Villain in the Development of Alcoholic Liver Disease. Editorial.Cell Mol Gastroenterol Hepatol. 2:544-545. doi: 10.1016/j.jcmgh.2016.06.005

PubMedID: 28174735
PubMed Central ID: 

Chen, S., Lu, W., Yueh, M.-F., Rettenmeier, E., Liu, M., Auwerx, J., Yu, R.T., Evans, R.M., Wang, K., Karin, M., Tukey, R.H. (2017) Intestinal NCoR1, a newly discovered regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.  Proc. Nat. Acad. Sci. USA.114:E1432-E1440. doi: 10.1073/pnas.1700232114.

PubMedID: 28167773
PubMed Central ID: 

Hirashima R., Itoh T., Tukey R.H., Fujiwara R. (2017) Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. doi: 10.1002/jat.3435.

PubMedID: 28138970
PubMed Central ID: 

Dulai P.S., Singh S., Patel J., Soni M., Prokop L.J., Younossi Z., Sebastiani G., Ekstedt M., Hagstrom H., Nasr P., Stal P., Wong V.W., Kechagias S., Hultcrantz R., Loomba R. (2017) Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis. Hepatology. 65(5):1557-1565. doi: 10.1002/hep.29085. Epub 2017 Mar 31.

PubMedID: 28130788
PubMed Central ID: 

Lin S.C., Heba E., Bettencourt R., Lin G.Y., Valasek M.A., Lunde O., Hamilton G., Sirlin C.B., Loomba R. (2017) Assessment of treatment response in non-alcoholic steatohepatitis using advanced magnetic resonance imaging. Aliment Pharmacol Ther. 45(6):844-854. doi: 10.1111/apt.13951. Epub 2017 Jan 24.

PubMedID: 28116801
PubMed Central ID: 

Sherman M.H., Yu R.T., Tseng T.W., Sousa C.M., Liu S., Truitt M.L., He N., Ding N., Liddle C., Atkins A.R., Lebland M., Collisson E.A., Asara J.M., Kimmelman A.C., Downes M., Evans R.M. (2017) Stromal cues regulate the pancreatic cancer epigenome and metabolome.  Proc Natl Acad Sci U S A. 114: 1129-1134. doi: 10.1073/pnas.1620164114.

PubMedID: 28096419
PubMed Central ID: 

Hinds T.D. Jr., Hosick P.A., Chen S., Tukey R.H., Hankins M.W., Nestor-Kalinoski A., Stec D.E. (2017) Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα. Am J Physiol Endocrinol Metab. 312(4):E244-E252. doi: 10.1152/ajpendo.00396.2016.

PubMedID: 28096081
PubMed Central ID: 

Koyama Y., Brenner D.A. (2017) Liver inflammation and fibrosis. J Clin Invest. 127:55-64. doi: 10.1172/JCI88881.

PubMedID: 28045404
PubMed Central ID: 

Chung H.K., Ryu D., Kim K.S., Chang J.Y., Kim Y.K., Yi H.-S., Kang S.G., Choi M.J., Lee S.E., Jung S.B., Ryu M.J., Kim S.J., Kweon G.R., Kim H., Hwang J.H., Lee C.-H., Lee S.-J., Wall C.E., Downes M., Evans R.M., Auwerx J., Shong M. (2017) Growth differentiation factor 15 (GDF15) is a myomitokine governing systemic energy homeostasis. J Cell Biol. 216: 149-165. doi: 10.1083/jcb.201607110.

PubMedID: 27986797
PubMed Central ID: 

Park C.C., Nguyen P., Hernandez C., Bettencourt R., Ramirez K., Fortney L., Hooker J., Sy E., Savides M.T., Alquiraish M.H., Valasek M.A., Rizo E., Richards L., Brenner D., Sirlin C.B., Loomba R. (2017) Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Gastroenterology. 152:598-607. doi: 10.1053/j.gastro.2016.10.026.

PubMedID: 27911262
PubMed Central ID: 

Fan W., Evans R.M.. (2017) Exercise Mimetics: Impact on Health and Performance. Cell Metab. 25:(2)242-247. doi: 10.1016/j.cmet.2016.10.022.

PubMedID: 27889389
PubMed Central ID: 

Moscat, J., Karin, M., Diaz-Meco, M.T. (2016) p62 in Cancer: Signaling Adaptor Beyond Autophagy. Cell. 167:606-609. doi:10.1016/j.cell.2016.09.030.

PubMedID: 27768885
PubMed Central ID: 

Duran, A., Hernandez, E.H, Reina-Campos, M, Castilla, E.A., Subramaniam, S., Raghunandan, S., Roberts, L.R., Kisseleva, T., Karin, M., Diaz-Meco, M.T., Moscat, J. (2016) p62/SQSTM1 by binding to vitamin D receptor inhibits hepatic stellate cell activity, fibrosis and liver cancer. Cancer Cell. 30:595-609. doi: 10.1016/j.ccell.2016.09.004

PubMedID: 27728806
PubMed Central ID: 

Mitsugi R., Sumida K., Fujie Y., Tukey R.H., Itoh T., Fujiwara R. Acyl-glucuronide as a Possible Cause of Trovafloxacin-Induced Liver Toxicity: Induction of Chemokine (C-X-C Motif) Ligand 2 by Trovafloxacin Acyl-glucuronide. (2016) Biol Pharm Bull. 39(10):1604-1610. doi: 10.1248/bpb.b16-00195.

PubMedID: 27725437
PubMed Central ID: 

Schoeller E.L., Clark D.D., Dey S., Cao N.V., Semaan S.J., Chao L.W., Kauffman A.S., Stowers L., Mellon P.L. (2016) Bmal1 Is Required for Normal Reproductive Behaviors in Male Mice. Endocrinology. 157:4914-4929. doi: 10.1210/en.2016-1620

PubMedID: 27704948
PubMed Central ID: 

Guo, L., Ganguly, A., Sun, L., Suo, F., Du, L.L., Russell. P. (2016) Global fitness profiling identifies arsenic and cadmium tolerance mechanisms in fission yeast. G3 (Bethesda). 6:3317-3333. doi: 10.1534/g3.116.033829.

 

PubMedID: 27558664
PubMed Central ID: 

Stephan A.B., Kunz H.H., Yang E., Schroeder J.I. (2016) Rapid hyperosmotic-induced Ca2+ responses in Arabidopsis thaliana exhibit sensory potentiation and involvement of plastidial KEA transporters. Proc Natl Acad Sci U S A. 113(35):E5242-9. doi: 10.1073/pnas.1519555113. Epub 2016 Aug 15.

PubMedID: 27528686
PubMed Central ID: 

Hirashima R., Michimae H., Takemoto H., Sasaki A., Kobayashi Y., Itoh T., Tukey R.H., Fujiwara R. (2016) Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity. Mol Pharmacol. 90:265-74. doi: 10.1124/mol.116.104174.

PubMedID: 27413119
PubMed Central ID: 

Taniguchi, K., Yamachika, S., He, F., Karin, M. (2016) p62/SQSTM1- Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer. FEBS Lett. 590:2375-97.doi: 10.1002/1873-3468.12301

PubMedID: 27404485
PubMed Central ID: 

Huang P.P., Brusman L.E., Iyer A.K., Webster N.J., Mellon P.L. (2016) A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models. PLoS One. 11(7):e0158597. doi: 10.1371/journal.pone.0158597. eCollection 2016.

PubMedID: 27389022
PubMed Central ID: 

Aleman F., Yazaki J., Lee M., Takahashi Y., Kim A.Y., Li Z., Kinoshita T., Ecker J.R., Schroeder J.I. (2016) An ABA-increased interaction of the PYL6 ABA receptor with MYC2 Transcription Factor: A putative link of ABA and JA signaling. Sci Rep. 6:28941. doi: 10.1038/srep28941.

PubMedID: 27357749
PubMed Central ID: 

Yazaki J., Galli M., Kim A.Y., Nito K., Aleman F., Chang K.N., Carvunis A.R., Quan R., Nguyen H., Song L., Alvarez J.M., Huang S.S., Chen H., Ramachandran N., Altmann S., Gutiérrez R.A., Hill D.E., Schroeder J.I., Chory J., LaBaer J., Vidal M., Braun P., Ecker J.R. (2016) Mapping transcription factor interactome networks using HaloTag protein arrays. Proc Natl Acad Sci U S A. 113:E4238-47.
doi: 10.1073/pnas.1603229113.

PubMedID: 27357687
PubMed Central ID: 

Koyama Y., Xu J., Liu X., Brenner D.A. (2016) New Developments on the Treatment of Liver Fibrosis. Dig Dis. 34:589-96. doi: 10.1159/000445269.

PubMedID: 27332862
PubMed Central ID: 

Lee, J.H., Cho, U.S., Karin, M. (2016) Sestrin regulation of TORC1: Is Sestrin a leucine sensor? Sci Signal. 9:re5. doi: 10.1126/scisignal.aaf2885

PubMedID: 27273098
PubMed Central ID: 

Umemura, A., He, F., Nakagawa, H., Yamachika, S., Taniguchi, K., Font-Burgada, J., Zhong, Z., Subramaniam, S., Raghunandan, S., Duran, A., Linares, J.F., Reina-Campos, M., Valasek, M.A., Seki, E., Yamaguchi, K., Koike, K., Itoh, Y., Diaz-Meco, M.T., Moscat, J., Karin, M. (2016) p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells. Cancer Cell. 29:935-48. doi: 10.1016/j.ccell.2016.04.006.

PubMedID: 27211490
PubMed Central ID: 

Karin, M., Dhar, D. (2016) Liver Carcinogenesis: From Naughty Chemicals to Soothing Fat- and the Suprising Role of NRF2. Carcinogenesis. 37:541-6. doi: 10.1093/carcin/bgw060

PubMedID: 27207669
PubMed Central ID: 

Hsin I.-F., Montano E., Seki E. (2016) Finding a New Role for NEMO: A Key Player in Preventing Hepatocyte Apoptosis and Liver Tumorigenesis by Inhibiting RIPK1. Hepatology Elsewhere. Hepatology. 64:295-7. doi: 10.1002/hep.28627.

PubMedID: 27122117
PubMed Central ID: 

Wall C.E., Yu R.T., Atkins A.R., Downes M., Evans R.M. (2016) Nuclear receptors and AMPK: can exercise mimetics cure diabetes?J Mol Endocrinol. 2016 Apr 22. pii: JME-16-0073. doi: 10.1530/JME-16-0073.

PubMedID: 27106806
PubMed Central ID: 

Yoshihara E., Wei Z., Lin C.S., Fang S., Ahmadian M., Kida Y., Tseng T., Dai Y., Yu R.T., Liddle C., Atkins A.R., Downes M., Evans R.M. (2016)  ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells.Cell Metab. 23:622-34. doi: 10.1016/j.cmet.2016.03.005.

PubMedID: 27076077
PubMed Central ID: 

Liu M., Chen S., Yueh M.F., Fujiwara R., Konopnicki C., Hao H., Tukey R.H. (2016) Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol. 110-111:37-46. doi:10.1016/j.bcp.2016.04.003.

PubMedID: 27060662

Pages