Superfund Publications

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PubMed Central ID: 

Pamenter, M. E., Perkins, G. A., Gu, X. Q., Ellisman, M. H., Haddad, G. G. (2013) DIDS (4,4-diisothiocyanatostilbenedisulphonic acid) induces apoptotic cell death in a hippocampal neuronal cell line and is not neuroprotective against ischemic stress. PLoS One. 10.1371/journal.pone.0060804.

PubMedID: 23577164
PubMed Central ID: 

Konopnicki, C. M., Dickmann, L. J., Tracy, J. M., Tukey, R. H., Wienkers, L. C., Foti, R. S. (2013) Evaluation of UGT protein interactions in human hepatocytes: effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes. Arch Biochem Biophys. 535(2):143-9. doi: 10.1016/j.abb.2013.03.012.

PubMedID: 23562620
PubMed Central ID: 

Glidewell-Kenney, C. A., Shao, P. P., Iyer, A. K., Grove, A. M., Meadows, J. D., Mellon, P. L. (2013) Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol. Endocrinol. 27(3), 437-54.

PubMedID: 23393128
PubMed Central ID: 

Yang, L., Inokuchi, S., Roh, Y. S., Song, J., Loomba, R., Park, E. J., Seki, E. (2013) Transforming growth factor-β signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. Gastroenterology. 144(5), 1042-1054.

PubMedID: 23391818
PubMed Central ID: 

Clark, D. D., Gorman, M. R., Hatori, M., Meadows, J. D., Panda, S., Mellon, P. L. (2013) Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6. J. Biol. Rhythms. 28(1), 15-25.

PubMedID: 23382588
PubMed Central ID: 

Xie, H., Cherrington, B. D., Meadows, J. D., Witham, E. A., Mellon, P. L. (2013) Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development. Mol. Endocrinol. 27(3), 422-36.

PubMedID: 23371388
PubMed Central ID: 

Du, H., Sun, X., Guma, M., Luo, J., Ouyang, H., Zhang, X., Zeng, J., Quach, J., Nguyen, D. H., Shaw, P. X., Karin, M., Zhang, K. (2013) JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc. Natl. Acad. Sci. USA. 110(6), 2377-82.

PubMedID: 23341606
PubMed Central ID: 

Du, H., Sun, X., Guma, M., Luo, J., Ouyang, H., Zhang, X., Zeng, J., Quach, J., Nguyen, D. H., Shaw, P. X., Karin, M., Zhang, K. (2013) JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci USA. 110(6), 2377-82. doi: 10.1073/pnas.1221729110.

PubMedID: 23341606
PubMed Central ID: 

Perkins, G. A., Scott, R., Perez, A., Ellisman, M. H., Johnson, J. E., Fox, D. A.. (2012) Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption. Mol Vis. 18, 3029-48

PubMedID: 23288995
PubMed Central ID: 

Sakurai, T., Kudo, M., Umemura, A., He, G., Elsharkawy, A. M., Seki, E., Karin, M. (2013) p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res. 73(1), 215-24. doi: 10.1158/0008-5472.CAN-12-1602.

PubMedID: 23271722
PubMed Central ID: 

Uhlenhaut, N. H., Barish, G. D., Yu, R. T., Downes, M., Karunasiri, M., Liddle, C., Schwalie, P., Hübner, N., Evans, R. M. (2013) Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. Mol Cell. 49(1):158-71. doi: 10.1016/j.molcel.2012.10.013.

PubMedID: 23159735
PubMed Central ID: 

Yu, G. Y., He, G., Li, C. Y., Tang, M., Grivennikov, S., Tsai, W. T., Wu, M. S., Hsu, C. W., Tsai, Y., Wang, L. H., Karin, M. (2012) Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol. Cell. 48(2), 313-21.

PubMedID: 22959272
PubMed Central ID: 

Yu, G. Y., He, G., Li, C. Y., Tang, M., Grivennikov, S., Tsai, W. T., Wu, M. S., Hsu, C. W., Tsai, Y., Wang, L. H., Karin, M. (2012) Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell. 48(2), 313-21. doi: 10.1016/j.molcel.2012.07.032.

PubMedID: 22959272
PubMed Central ID: 

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H. W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., Wolfe, A. M., Perkins, G. A., Ellisman, M. H., Bier, E., Scadeng, M., Foretz, M., Viollet, B., Olefsky, J., Karin, M. (2012) Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell. Metab. 16(3), 311-21.

PubMedID: 22958918
PubMed Central ID: 

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H. W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., Wolfe, A. M., Perkins, G. A., Ellisman, M. H., Bier, E., Scadeng, M., Foretz, M., Viollet, B., Olefsky, J., Karin, M. (2012) Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 16(3), 311-21. doi: 10.1016/j.cmet.2012.08.004.

PubMedID: 22958918
PubMed Central ID: 

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H. W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., Wolfe, A. M., Perkins, G. A., Ellisman, M., Bier, E., Scadeng, M., Foretz, M., Viollet, B., Olefsky, J., Karin, M. (2012) Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab.16(3), 311-21.

PubMedID: 22958918
PubMed Central ID: 

Li, T., Yu, R. T., Atkins, A. R., Downes, M., Tukey, R. H., Evans, R. M. (2012) Targeting the pregnane X receptor in liver injury. Expert Opin Ther Targets16(11):1075-83. doi: 10.1517/14728222.2012.715634.

PubMedID: 22913318
PubMed Central ID: 

Brayman, M. J., Pepa, P. A., Mellon, P. L. (2012) Androgen receptor repression of gonadotropin-releasing hormone gene transcription via enhancer 1. Mol. Cell. Endocrinol. 363(1-2), 92-9.

PubMedID: 22877652
PubMed Central ID: 

Falivelli, G., De Jaco, A., Favaloro, F. L., Kim, H., Wilson, J., Dubi, N., Ellisman, M. H., Abrahams, B. S., Taylor, P., Comoletti, D. (2012) Inherited genetic variants in autism-related CNTNAP2 show perturbed trafficking and ATF6 activation. Hum Mol Genet. 21(21), 4761-73.

PubMedID: 22872700
PubMed Central ID: 

Pohaku Mitchell, K. K., Liberman, A., Kummel, A. C., Trogler, W. C. (2012) Iron(III)-doped, silica nanoshells: a biodegradable form of silica. J Am Chem Soc. 134(34), 13997-4003.

PubMedID: 22871140
PubMed Central ID: 

Breen, K. M., Thackray, V. G., Hsu, T., Mak-McCully, R. A., Coss, D., Mellon, P. L. (2012) Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells. Mol. Endocrinol. 26(10), 1716-31.

PubMedID: 22851703
PubMed Central ID: 

Witham, E. A., Meadows, J. D., Shojaei, S., Kauffman, A. S., Mellon, P. L. (2012) Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology. 153(9), 4522-32.

PubMedID: 22778229
PubMed Central ID: 

Witham, E. A., Meadows, J. D., Shojaei, S., Kauffman, A. S., Mellon, P. L. (2012) Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology. 153(9), 4522-32.

PubMedID: 22778229
PubMed Central ID: 

Yueh, M. F., Li, T., Evans, R. M., Hammock, B., Tukey, R. H. (2012) Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS One7(6):e37705. doi: 10.1371/journal.pone.0037705.

PubMedID: 22761658
PubMed Central ID: 

Seki, E., Brenner, D. A., Karin, M. (2012) A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 143(2), 307-20. doi: 10.1053/j.gastro.2012.06.004.

PubMedID: 22705006

Font-Burgada, J., Seki, E., Karin, M. (2012) CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction. Cancer Cell. 21(6), 711-2

PubMedID: 22698394
PubMed Central ID: 

Font-Burgada, J., Seki, E., Karin, M. (2012) CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction. Cancer Cell. 21(6), 711-2. doi: 10.1016/j.ccr.2012.05.034.

PubMedID: 22698394

Font-Burgada, J., Seki, E., Karin, M. (2012) CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction. Cancer Cell. 21(6), 711-2.

PubMedID: 22698394
PubMed Central ID: 

Guo, L., Ghassemian, M., Komives, E. A., Russell, P. (2012) Cadmium-induced proteome remodeling regulated by Spc1/Sty1 and Zip1 in fission yeast. Toxicol Sci. 129(1), 200-12.

PubMedID: 22610605

 Abe, Y., Uchinami, H., Kudoh, K., Nakagawa, Y., Ise, N., Watanabe, G., Sato, T., Seki, E., Yamamoto, Y. (2012)  Liver epithelial cells proliferate under hypoxia and protect the liver from ischemic injury via expression of HIF-1 alpha target genes. Surgery. 152(5), 869-78.

PubMedID: 22575885
PubMed Central ID: 

Fan, W., Downes, M., Atkins, A., Yu, R., Evans, R. M. (2011) Nuclear receptors and AMPK: resetting metabolism. Cold Spring Harb Symp Quant Biol. 76:17-22. doi: 10.1101/sqb.2012.76.010470.

PubMedID: 22411605
PubMed Central ID: 

Chen, S., Yueh, M. F., Evans, R. M., Tukey, R. H. (2012) Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice. Hepatology. 56(2):658-67. doi: 10.1002/hep.25671.

PubMedID: 22371261
PubMed Central ID: 

Noreault-Conti, T. L., Fellows, A., Jacobs, J. M., Trask, H. W., Strom, S. C., Evans, R. M., Wrighton, S. A., Sinclair, P. R., Sinclair, J. F., Nichols, R. C. (2012) Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes. Int Immunopharmacol. 12(4):651-6. doi: 10.1016/j.intimp.2012.01.008.

PubMedID: 22310326
PubMed Central ID: 

Ghochani, Y., Saini, J. K., Mellon, P. L., Thackray, V. G. (2012) FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter. Endocrinology. 153(4), 2023-33.

PubMedID: 22294749
PubMed Central ID: 

Jobe, T. O., Sung, D. Y., Akmakjian, G., Pham, A., Komives, E. A., Mendoza-Cózatl, D. G., Schroeder, J. I. (2012) Feedback inhibition by thiols outranks glutathione depletion: a luciferase-based screen reveals glutathione-deficient γ-ECS and glutathione synthetase mutants impaired in cadmium-induced sulfate assimilation. Plant J. 70(5), 783-95. doi: 10.1111/j.1365-313X.2012.04924.x.

PubMedID: 22283708

Jobe, T. O., Sung, D. Y., Akmakjian, G., Pham, A., Komives, E. A., Mendoza-Cózatl, D. G., Schroeder, J. I. (2012) Feedback inhibition by thiols outranks glutathione depletion: a luciferase-based screen reveals glutathione-deficient γ-ECS and glutathione synthetase mutants impaired in cadmium-induced sulfate assimilation. Plant J. 70(5), 783-95.

PubMedID: 22283708
PubMed Central ID: 

Sun, B., Karin, M. (2012) Obesity, inflammation, and liver cancer. J Hepatol. 56(3), 704-13. doi: 10.1016/j.jhep.2011.09.020.

PubMedID: 22120206
PubMed Central ID: 

Brayman, M. J., Pepa, P. A., Berdy, S. E., Mellon, P. L. (2012) Androgen receptor repression of GnRH gene transcription. Mol. Endocrinol. 26(1), 2-13.

PubMedID: 22074952
PubMed Central ID: 

Brayman, M. J., Pepa, P. A., Berdy, S. E., Mellon, P. L. (2012) Androgen receptor repression of GnRH gene transcription. Mol. Endocrinol. 26(1), 2-13.

PubMedID: 22074952
PubMed Central ID: 

Fujiwara, R., Chen, S., Karin, M., Tukey, R. H. (2012) Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 142(1), 109-118.

PubMedID: 21983082
PubMed Central ID: 

Fujiwara, R., Chen, S., Karin, M., Tukey, R.H. (2012) Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 142(1), 109-118. doi: 10.1053/j.gastro.2011.09.045.

PubMedID: 21983082
PubMed Central ID: 

Fujiwara, R., Chen, S., Karin, M., Tukey, R. H. (2012) Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 142(1), 109-118.

PubMedID: 21983082
PubMed Central ID: 

Holzer, R. G., Park, E. J., Li, N., Tran, H., Chen, M., Choi, C., Solinas, G., Karin, M. (2011) Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell. 147(1), 173-84. doi: 10.1016/j.cell.2011.08.034.

PubMedID: 21962514
PubMed Central ID: 

Xue, S., Yao, X., Luo, W., Jha, D., Tester, M., Horie, T., Schroeder, J. I. (2011) AtHKT1;1 mediates nernstian sodium channel transport properties in Arabidopsis root stelar cells. PLoS One. 6(9):e24725. doi: 10.1371/journal.pone.0024725.

PubMedID: 21931830
PubMed Central ID: 

Mendoza-Cózatl, D.G., Jobe, T. O., Hauser, F., Schroeder, J. I. (2011) Long-distance transport, vacuolar sequestration, tolerance, and transcriptional responses induced by cadmium and arsenic. Curr Opin Plant Biol. 14(5), 554-62. doi: 10.1016/j.pbi.2011.07.004.

PubMedID: 21820943
PubMed Central ID: 

Rodríguez-Gabriel, M. A., Russell, P. (2008) Control of mRNA stability by SAPKs. Top Curr Genet. 20, 159-170.

PubMedID: 21738496
PubMed Central ID: 

Jannat, R., Uraji, M., Morofuji, M., Islam, M. M., Bloom, R. E., Nakamura, Y., McClung, C. R., Schroeder, J. I., Mori, I. C., Murata, Y. (2011) Roles of intracellular hydrogen peroxide accumulation in abscisic acid signaling in Arabidopsis guard cells. J Plant Physiol. 168(16),1919-26. doi: 10.1016/j.jplph.2011.05.006.

PubMedID: 21665322
PubMed Central ID: 

Horie, T., Brodsky, D. E., Costa, A., Kaneko, T., Lo Schiavo, F., Katsuhara, M., Schroeder, J. I. (2011) K+ transport by the OsHKT2;4 transporter from rice with atypical Na+ transport properties and competition in permeation of K+ over Mg2+ and Ca2+ ions. Plant Physiol. 156(3), 1493-507. doi: 10.1104/pp.110.168047.

PubMedID: 21610181
PubMed Central ID: 

​Hauser, F. Waadt, R. & Schroeder, J. I. (2011) Evolution of abscisic acid synthesis and signaling mechanisms. Curr Biol. doi: 10.1016/j.cub.2011.03.015.

PubMedID: 21549957
PubMed Central ID: 

Kacevska, M., Downes, M. R., Sharma, R., Evans, R. M., Clarke, S. J., Liddle, C., Robertson, G. R. (2011) Extrahepatic cancer suppresses nuclear receptor-regulated drug metabolism. Clin Cancer Res. 17(10):3170-80. doi: 10.1158/1078-0432.CCR-10-3289.

PubMedID: 21498392

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