Superfund Publications

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PubMed Central ID: 

Lee, J. H., Bodmer, R., Bier, E., Karin, M. (2010) Sestrins at the crossroad between stress and aging. Aging (Albany NY). 2(6), 369-74. doi: 10.18632/aging.100157

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Rodriguez-Gabriel, M. A., Russell, P. (2008) Control of mRNA stability by SAPKs. Topics Curr Genet. 20, 50-166.

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Li, J-Y., Fu, Y-L., Pike, S.M., Bao, J., Tian, W., Zhang, Y., Chen, C-Z., Zhang, Y., Li, H-M., Huang, J., Li, L-G., Schroeder, J.I., Gassmann, W., Gong, J-M. The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal from the xylem and mediates cadmium tolerance. Plant Cell 22: 1633-46 (2010).

PubMed Central ID: 

Argikar, U.A., Senekeo-Effenberger, K., Larson, E.E., Tukey, R.H., Remmel, R.P. (2009) Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica. 39(11):826-35. doi: 10.3109/00498250903188985.

PubMed Central ID: 

Costa, A., Drago, I., Behera, S., Zottini, M., Pizzo, P., Schroeder, J. I., Pozzan, T., Schiavao, F. L. (2010) H(2)O(2) in plant peroxisomes: an in vivo analysis uncovers a Ca(2+)-dependent scavenging system. Plant J. 62(5), 760-772. doi: 10.1111/j.1365-313X.2010.04190.x.

PubMed Central ID: 

Pyo, Y.J., Gierth, M., Schroeder, J.I., Cho, M.H. (2010) High-affinity K+ transport in Arabidopsis: AtHAK5 and AKT1 are vital for seedling establishment and postgermination growth under low-potassium conditions. Plant Physiol. 153, 863-75.

PubMed Central ID: 

Cai, H., Nguyen, N., Peterkin, V., Young-Sun, Y., Hotz, K., Beaton-La Placa, D., Chen, S., Tukey, R. H., and Stevens, J. C. (2010) A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1 dependent glucuronidation. Drug Metabol Dispos. 38(5), 879-86. doi: 10.1124/dmd.109.030130.

PubMed Central ID: 

Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., Karin, M. (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 327(5970),1223-8. doi: 10.1126/science.1182228.

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Vahisalu, T., Kollist, H., Wang, Y. F., Nishimura, N., Chan, W. Y., Valerio, G., Lamminmaki, A., Brosche, M., Moldau, H., Desikan, R., Schroeder, J. I., Kangasjarvi, J. (2008) SLAC1 is required for plant guard cell S‐type anion channel function in stomatal signalling. Nature. 452, 487‐91. doi: 10.1038/nature06608.

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Sadi, B. B., Vonderheide, A. P., Gong, J. M., Schroeder, J. I., Shann, J. R. & Caruso, J. A. (2008) An HPLC-ICP-MS technique for determination of cadmium-phytochelatins in genetically modified Arabidopsis thaliana. J Chromatogr B Analyt Technol Biomed Life Sci. 861,123-9. doi: 10.1016/j.jchromb.2007.11.004

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Fujiwara, R., Nguyen, N., Chen, S., Tukey, R. H. (2010) Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP-glucuronosyltransferase 1 (UGT1) locus. Proc Natl Acad Sci USA. 107(11), 5024-5029. doi: 10.1073/pnas.0913290107.

PubMed Central ID: 

He, G., Yu, G. Y., Temkin, V., Ogata, H., Kuntzen, C., Sakurai, T., Sieghart, W., Peck-Radosavlijevic, M., Leffert, H. L., Karin, M. (2010) Hepatocyte IKKB/NF-KB inhibits tumor promotion and progression by preventing oxidative stress driven STAT3 activation. Cancer Cell. 17(3), 286-297. doi: 10.1016/j.ccr.2009.12.048.

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Mendoza-Cozatl, D. G., Butko, E., Springer, F., Torpey, J. W., Komives, E. A., Kehr, J., Schroeder, J. I. (2008)  Identification of high levels of phytochelatins, glutathione and cadmium in the phloem sap of Brassica napus. A role for thiol-peptides in the long-distance transport of cadmium and the effect of cadmium on iron translocation. Plant Journal. 54,  249-59. 54(2):249-59. doi: 10.1111/j.1365-313X.2008.03410.x.

PubMed Central ID: 

Park, E., Lee, J., Yu, G. Y., He, G., Ali, S., Holzer, R., Osterreicher, C., Takahashi, H., Karin, M. (2010) Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 140, 197-208. doi: 10.1016/j.cell.2009.12.052.

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Nishimura, N., Hitomi, K., Arvai, A. S., Rambo, R. P., Hitomi, C., Cutler, S. R., Schroeder, J. I., Getzoff, E. D. (2009) Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science. 326(5958), 1373-9. doi: 10.1126/science.1181829.

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Sung, D. Y., Kim, T. H., Komives, E. A., Mendoza-Cózatl, D. G., Schroeder, J. I. (2009)  ARS5 is a component of the 26S proteasome complex, and negatively regulates thiol biosynthesis and arsenic tolerance in Arabidopsis. Plant J. 59(5):802-13. doi: 10.1111/j.1365-313X.2009.03914.x.

PubMed Central ID: 

Vashisht, A. A., Kennedy, P. J., Russell, P. (2009) Centaurin-like protein Cnt5 contributes to arsenic and cadmium resistance in fission yeast. FEMS. Yeast Res. 9, 257-269.

PubMed Central ID: 

Takahashi, H., Ogata, H., Nishigaki, R., Broide, D. H., Karin, M. (2010) Tobacco smoke promotes lung tumorigenesis by triggering IKKb and JNK1 dependent inflammation. Cancer Cell. 17, 89-97. doi: 10.1016/j.ccr.2009.12.008.

PubMed Central ID: 

Nishimura, N., Sarkeshik, A., Nito, K., Park, S. Y., Wang, A., Carvalho, P. C., Lee, S., Caddell, D. F., Cutler, S. R., Chory, J., Yates, J. R., Schroeder, J. I. (2010) PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J. 61, 290-299. doi: 10.1111/j.1365-313X.2009.04054.x.

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Yao, X., Horie, T., Xue, S., Leung, H. Y., Katsuhara, M., Brodsky, D. E., Wu, Y. & Schroeder, J. I. (2010) Differential sodium and potassium transport selectivities of the rice OsHKT2;1 and OsHKT2;2 transporters in plant cells. Plant Physiol. 152, 341-55. doi: 10.1104/pp.109.145722.

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Horie, T., Hauser, F., Schroeder, J. I. (2009)  HKT transporter-mediated salinity resistance mechanisms in Arabidopsis and monocot crop plants. Trends Plant Sci. 14(12):660-8. doi: 10.1016/j.tplants.2009.08.009.

PubMed Central ID: 

Budanov, A. V., Karin, M. (2008) p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell. 134(3), 451-60. doi: 10.1016/j.cell.2008.06.028.

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Perkins, G., Bossy-Wetzel, E., Ellisman, M. H., (2009) New insights into mitochondrial structure during cell death. Exp Neurol. 218(2), 183-92.

PubMed Central ID: 
 Fabrichny, I. P., Leone, P., Sulzenbacher, G., Comoletti, D., Miller, M. T., Taylor, P., Bourne, Y., Marchot, P. (2007) Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion.
Neuron. 56(6), 979-91.
PubMed Central ID: 

Koch, K. S., Maeda, S., He, G., Karin, M., Leffert, H. L. (2009) Targeted deletion of hepatocyte IKKβ; confers growth advantages. Biochem Biophys Res Commun. 380, 349-354. doi: 10.1016/j.bbrc.2009.01.085.

PubMed Central ID: 

Naugler, W. E., Karin, M. (2008) NF-KappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev. 18(1), 19-26. doi: 10.1016/j.gde.2008.01.020.

PubMed Central ID: 

Kennedy, P. J., Vashisht, A. A., Hoe, K. L., Kim, D. U., Park, H. O., Hayles, J., Russell, P. A. (2008) genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe. Toxicol Sci. 106(1), 124-39.

PubMed Central ID: 

Kim, Y. Y., Kim, D. Y., Shim, D., Song, W. Y., Lee, J., Schroeder, J. I., Kim, S., Moran, N., Lee Y. (2008)  Expression of the Novel Wheat Gene TM20 Confers Enhanced Cadmium Tolerance to Bakers Yeast. J Biol Chem. 283, 15893-15892. doi: 10.1074/jbc.M708947200.

PubMed Central ID: 

Horie, T., Costa, A., Kim, T. H., Han, M. H., Horie, R., Leung, H. Y., Miyao, A., Hirochika, H., An, G. and Schroeder, J.I. (2007) Rice OsHKT2;1 transporter mediates large Na+ influx component into K+-starved roots for growth. EMBO J. 26, 3003-3014. doi: 10.1038/sj.emboj.7601732.

PubMed Central ID: 

Pezzoli, K., Tukey, R., Sarabia, H., Zaslavsky, I., Miranda, M. L., Suk, W. A., Lin, A., Ellisman, M. (2007) The NIEHS Environmental Health Sciences Data Resource Portal: placing advanced technologies in service to vulnerable communities. Environ Health Perspect. 115(4), 564-71. doi: 10.1289/ehp.9817

PubMed Central ID: 

Sonoda, J., Mehl, I. R., Chong, L. W., Nofsinger, R. R., Evans, R. M. (2007) PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc Natl Acad Sci USA. 104(12):5223-8. doi: 10.1073/pnas.0611623104. 

PubMed Central ID: 

Stedman, C., Liddle, C., Coulter, S., Sonoda, J., Alvarez, J. G., Evans, R. M., and Downes, M. (2006) Benefit of FXR inhibition in obstructive cholestasis. Proc Natl Acad Sci USA. 103(30):11323-8. doi: 10.1073/pnas.0604772103

PubMed Central ID: 

Allen, G. J., Murata, Y., Chu, S. P., Nafisi, M., Schroeder, J. I. (2002) Hypersensitivity of abscisic acid-induced cytosolic calcium increases in the Arabidopsis farnesyltransferase mutant era1-2. Plant Cell. 14(7), 1649-62. doi: 10.1105/tpc.010448.

PubMed Central ID: 

Sakurai, T., Maeda, S., Chang, L., Karin, M. (2006)  Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci USA. 103(28),10544-51. doi: 10.1073/pnas.0603499103

PubMed Central ID: 

Kwak, J. M., Nguyen, V., Schroeder, J. I. (2006) The role of reactive oxygen species in hormonal responses. Plant Physiology. 141, 323-329. doi: 10.1104/pp.106.079004

PubMed Central ID: 

Chen, A., Komives, E. A., Schroeder, J. I. (2006) An improved grafting technique for mature Arabidopsis plants demonstrates long-distance shoot-to-root transport of phytochelatins in Arabidopsis. Plant Physiology. 141, 108-120. doi: 10.1104/pp.105.072637.

PubMed Central ID: 

Mäser, P., Hosoo, Y., Goshima, S., Horie, T., Eckelman, B., Yamada, K., Yoshida, K., Bakker, E. P., Shinmyo, A., Oiki, S., Schroeder, J. I., Uozumi, N. (2002) Glycine residues in potassium channel-like selectivity filters determine potassium selectivity in four-loop-per-subunit HKT transporters from plants. Proc Natl Acad Sci USA. 99(9), 6428-33. doi: 10.1073/pnas.082123799.

PubMed Central ID: 

Rodriguez-Gabriel, M. A., Russell, P. (2005) Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe. Eukaryotic Cell. 4(8), 1396-1402.

PubMed Central ID: 

Cao Q., Zhao X., Bai J., Gery S., Sun H., Lin D.C., Chen Q., Chen Z., Mack L., Yang H., Deng R., Shi X., Chong L.W., Cho H., Xie J., Li Q.Z., Müschen M., Atkins A.R., Liddle C., Yu R.T., Alkan S., Said J.W., Zheng Y., Downes M., Evans R.M., Koeffler H.P. (2017) Circadian clock cryptochrome proteins regulate autoimmunity. Proc Natl Acad Sci U S A. 114(47):12548-12553. doi: 10.1073/pnas.1619119114.

PubMed Central ID: 

Yang, Y. M., Roh, Y. S., Seki, E. (2015) MafG, A Novel Target of FXR that Regulates Bile Acid Homeostasis. Gastroenterology. 149(7), 1981-3.

PubMed Central ID: 

Valledor, A. F., Hsu, L. C., Ogawa, S., Sawka-Verhelle, D., Karin, M., Glass, C. K. (2004) Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci USA. 101(51), 17813-8. doi: 10.1073/pnas.0407749101

PubMed Central ID: 

Yazaki J., Galli M., Kim A.Y., Nito K., Aleman F., Chang K.N., Carvunis A.R., Quan R., Nguyen H., Song L., Alvarez J.M., Huang S.S., Chen H., Ramachandran N., Altmann S., Gutiérrez R.A., Hill D.E., Schroeder J.I., Chory J., LaBaer J., Vidal M., Braun P., Ecker J.R. (2016) Mapping transcription factor interactome networks using HaloTag protein arrays. Proc Natl Acad Sci U S A. 113:E4238-47.
doi: 10.1073/pnas.1603229113.

PubMed Central ID: 

Moles, A., Murphy, L., Wilson, C. L., Chakraborty, J. B., Fox, C., Park, E. J., Mann, J., Oakley, F., Howarth, R., Brain, J., Masson, S., Karin, M., Seki, E., Mann, D. A. (2014) A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J. Hepatol. 60(4), 782-91.

PubMed Central ID: 

Witham, E. A., Meadows, J. D., Hoffmann, H. M., Shojaei, S., Coss, D., Kauffman, A. S., Mellon, P. L. (2013)  Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol. Endocrinol27(8), 1283-94.

PubMed Central ID: 

Du, H., Sun, X., Guma, M., Luo, J., Ouyang, H., Zhang, X., Zeng, J., Quach, J., Nguyen, D. H., Shaw, P. X., Karin, M., Zhang, K. (2013) JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc. Natl. Acad. Sci. USA. 110(6), 2377-82.

PubMed Central ID: 

Witham, E. A., Meadows, J. D., Shojaei, S., Kauffman, A. S., Mellon, P. L. (2012) Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology. 153(9), 4522-32.

PubMed Central ID: 

Österreicher, C.H., Penz-Österreicher, M., Grivennikov, S. I., Guma, M., Koltsova, E. K., Datz, C., Sasik, R., Hardiman, G., Karin, M., Brenner, D. A. (2011) Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc. Natl. Acad. Sci. USA. 108(1), 308-13.

PubMed Central ID: 

Sakurai, T., Maeda, S., Chang, L., Karin, M. (2006)  Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc. Natl. Acad. Sci. USA. 103(28),10544-51.

PubMed Central ID: 

Lee, J. H., Budanov, A. V., Karin, M. (2013) Sestrins orchestrate cellular metabolism to attenuate aging. Cell. Metab. 18(6), 792-801.

PubMed Central ID: 

Yu, G. Y., He, G., Li, C. Y., Tang, M., Grivennikov, S., Tsai, W. T., Wu, M. S., Hsu, C. W., Tsai, Y., Wang, L. H., Karin, M. (2012) Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol. Cell. 48(2), 313-21.

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