Superfund Publications

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PubMed Central ID: 

Schnabl, B., Brenner, D. A. (2014) Interactions between the intestinal microbiome and liver diseases. Gastroenterology. 146(6):1513-24. doi: 10.1053/j.gastro.2014.01.020.

PubMedID: 24440671
PubMed Central ID: 

Dhar, D., Seki, E., Karin, M. (2014) NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet. Cell Metab. 19(1), 6-7. doi: 10.1016/j.cmet.2013.12.010.

PubMedID: 24411937
PubMed Central ID: 

Yueh, M. F., Chen, S., Nguyen, N., Tukey, R. H. (2014) Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J Biol Chem. 289(8), 4699-709. doi: 10.1074/jbc.M113.518613.

PubMedID: 24403077
PubMed Central ID: 

Yueh, M. F., Chen, S., Nguyen, N., Tukey, R. H. (2014) Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J. Biol. Chem. 289(8), 4699-709.

PubMedID: 24403077
PubMed Central ID: 

Roh, Y. S., Park, S., Kim, J. W., Lim, C. W., Seki, E., Kim, B. (2013) Toll-like receptor 7-mediated Type I Interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis. Hepatology. 10.1002/hep.26981.

PubMedID: 24375615
PubMed Central ID: 

Kudoh, K., Uchinami, H., Yoshioka, M., Seki, E., Yamamoto, Y. (2013) Nrf2 Activation Protects the Liver From Ischemia/Reperfusion Injury in Mice. Ann Surg. 260(1),118-27.

PubMedID: 24368646
PubMed Central ID: 

Moles, A., Murphy, L., Wilson, C. L., Chakraborty, J. B., Fox, C., Park, E. J., Mann, J., Oakley, F., Howarth, R., Brain, J., Masson, S., Karin, M., Seki, E., Mann, D. A. (2014) A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J. Hepatol. 60(4), 782-91.

PubMedID: 24333183
PubMed Central ID: 

Moles, A., Murphy, L., Wilson, C. L., Chakraborty, J. B., Fox, C., Park, E. J., Mann, J., Oakley, F., Howarth, R., Brain, J., Masson, S., Karin, M., Seki, E., Mann, D. A. (2014) A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol. 60(4), 782-91. doi: 10.1016/j.jhep.2013.12.005.

PubMedID: 24333183
PubMed Central ID: 

Moles, A., Murphy, L., Wilson, C. L., Chakraborty, J. B., Fox, C., Park, E. J., Mann, J., Oakley, F., Howarth, R., Brain, J., Masson, S., Karin, M., Seki, E., Mann, D. A. (2014) A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol. 60(4), 782-91.

PubMedID: 24333183
PubMed Central ID: 

Song, W. Y., Mendoza-Cózatl, D. G., Lee, Y., Schroeder, J. I., Ahn, S. N., Lee, H. S., Wicker, T., Martinoia, E. (2014) Phytochelatin-metal(loid) transport into vacuoles shows different substrate preferences in barley and Arabidopsis. Plant Cell Environ. 37(5), 1192-201. doi: 10.1111/pce.12227.

PubMedID: 24313707
PubMed Central ID: 

Fan, W., Atkins, A. R., Yu, R. T., Downes, M., Evans, R. M. (2013) Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. J Mol Endocrinol. 51(3):T87-T100. doi: 10.1530/JME-13-0258.

PubMedID: 24280961
PubMed Central ID: 

Chen, S., Yueh, M. F., Bigo, C., Barbier, O., Wang, K., Karin, M., Nguyen, N., Tukey, R. H. (2013) Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci USA. 110,19143-19148. doi: 10.1073/pnas.1319123110.

PubMedID: 24191041
PubMed Central ID: 

Ding, N., Liddle, C., Evans, R. M., Downes, M. (2013) Hepatic actions of vitamin D receptor ligands: a sunshine option for chronic liver disease? Expert Rev Clin Pharmacol. 6(6):597-9. doi: 10.1586/17512433.2013.841078.

PubMedID: 24164608
PubMed Central ID: 

He, G., Dhar, D., Nakagawa, H., Font-Burgada, J., Ogata, H., Jiang, Y., Shalapour, S., Seki, E., Yost, S. E., Jepsen, K., Frazer, K. A., Harismendy, O., Hatziapostolou, M., Iliopoulos, D., Suetsugu, A., Hoffman, R. M., Tateishi, R., Koike, K., Karin, M. (2013) Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 155(2), 384-96. doi: 10.1016/j.cell.2013.09.031.

PubMedID: 24120137
PubMed Central ID: 

Shibuya, A., Itoh, T., Tukey, R. H., Fujiwara, R. (2013)  Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia. Sci Rep. doi: 10.1038/srep02903.

PubMedID: 24104695
PubMed Central ID: 

Lee, J. H., Budanov, A. V., Karin, M. (2013) Sestrins orchestrate cellular metabolism to attenuate aging. Cell. Metab. 18(6), 792-801.

PubMedID: 24055102
PubMed Central ID: 

Paik, Y. H., Kim, J., Aoyama, T., De Minicis, S., Bataller, R., Brenner, D. A. (2014) Role of NADPH Oxidases in Liver Fibrosis. Antioxid Redox Signal. 20(17):2854-72. doi: 10.1089/ars.2013.5619.

PubMedID: 24040957
PubMed Central ID: 

Madsen, D. H., Leonard, D., Masedunskas, A., Moyer, A., Jürgensen, H. J., Peters, D. E., Amornphimoltham, P., Selvaraj, A., Yamada, S. S., Brenner, D. A., Burgdorf, S., Engelholm, L. H., Behrendt, N., Holmbeck, K., Weigert, R., Bugge, T. H. (2013) M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway J Cell Biol. 202(6):951-66. doi: 10.1083/jcb.201301081.

PubMedID: 24019537
PubMed Central ID: 

Breen, K. M., Mellon, P. L. (2014) Influence of stress-induced intermediates on gonadotropin gene expression in gonadotrope cells. Mol. Cell. Endocrinol. 385(1-2), 71-7.

PubMedID: 24012628
PubMed Central ID: 

Yang, L., Roh, Y. S., Song, J., Zhang, B., Liu, C., Loomba, R., Seki, E. (2014) Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. Hepatology. 59(2), 483-95.

PubMedID: 23996730
PubMed Central ID: 

Hauser, F., Chen, W., Deinlein, U., Chang, K., Ossowski, S., Fitz, J., Hannon, G. J., Schroeder, J. I. (2013) A genomic-scale artificial microRNA library as a tool to investigate the functionally redundant gene space in Arabidopsis. Plant Cell. 25(8), 2848-63. doi: 10.1105/tpc.113.112805.

PubMedID: 23956262
PubMed Central ID: 

Sumida, K., Kawana, M., Kouno, E., Itoh, T., Takano, S., Narawa, T., Tukey, R. H., Fujiwara, R. (2013) Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia. Mol Pharmacol. 84(5):679-86. doi: 10.1124/mol.113.088112.

PubMedID: 23950218
PubMed Central ID: 

Kittayaruksakul, S., Zhao, W., Xu, M., Ren, S., Lu, J., Wang, J., Downes, M., Evans, R. M., Venkataramanan R, Chatsudthipong V, Xie W. (2013) Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation. Pharm Res. 30(9):2199-208. doi: 10.1007/s11095-013-1101-9.

PubMedID: 23896737
PubMed Central ID: 

Roh, Y. S., Seki, E. (2013) Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. J Gastroenterol Hepatol. 1, 38-42.

PubMedID: 23855294
PubMed Central ID: 

Larder, R., Kimura, I., Meadows, J., Clark, D. D., Mayo, S., Mellon, P. L. (2013) Gene dosage of Otx2 is important for fertility in male mice. Mol. Cell. Endocrinol. 377(1-2), 16-22.

PubMedID: 23811236
PubMed Central ID: 

Witham, E. A., Meadows, J. D., Hoffmann, H. M., Shojaei, S., Coss, D., Kauffman, A. S., Mellon, P. L. (2013)  Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol. Endocrinol27(8), 1283-94.

PubMedID: 23770611
PubMed Central ID: 

Witham, E. A., Meadows, J. D., Hoffmann, H. M., Shojaei, S., Coss, D., Kauffman, A. S., Mellon, P. L. (2013)  Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol. Endocrinol27(8), 1283-94.

PubMedID: 23770611
PubMed Central ID: 

McDowell, S. C., Akmakjian, G., Sladek, C., Mendoza-Cozatl, D., Morrissey, J. B., Saini, N., Mittler, R., Baxter, I., Salt, D. E., Ward, J. M., Schroeder, J. I., Guerinot, M. L., Harper, J. F. (2013) Elemental concentrations in the seed of mutants and natural variants of Arabidopsis thaliana grown under varying soil conditions. PLoS One. doi: 10.1371/journal.pone.0063014.

PubMedID: 23671651
PubMed Central ID: 

Du, L., Bergsneider, M., Mirsadraei, L., Young, S. H., Jonker, J. W., Downes, M., Yong, W. H., Evans, R. M., Heaney, A. P. (2013) Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease. Proc Natl Acad Sci USA. 110(21):8555-60. doi: 10.1073/pnas.1306182110.

PubMedID: 23653479
PubMed Central ID: 

Ahmadian, M., Suh, J. M., Hah, N., Liddle, C., Atkins, A. R., Downes, M., Evans, R. M. (2013) PPARγ signaling and metabolism: the good, the bad and the future. Nat Med. 19(5):557-66. doi: 10.1038/nm.3159.

PubMedID: 23652116
PubMed Central ID: 

Schroeder, J. I., Delhaize, E., Frommer, W. B., Guerinot, M. L., Harrison, M. J., Herrera-Estrella, L., Horie, T., Kochian, L. V., Munns, R., Nishizawa, N. K., Tsay, Y. F., Sanders, D. (2013) Using membrane transporters to improve crops for sustainable food production. Nature. 497(7447), 60-6. doi: 10.1038/nature11909.

PubMedID: 23636397
PubMed Central ID: 

Ding, N., Yu, R. T., Subramaniam, N., Sherman, M. H., Wilson, C., Rao, R., Leblanc, M., Coulter, S., He, M., Scott, C., Lau, S. L., Atkins, A. R., Barish, G. D., Gunton, J. E., Liddle, C., Downes, M., Evans, R. M. (2013) A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell. 153(3):601-13. doi: 10.1016/j.cell.2013.03.028.

PubMedID: 23622244
PubMed Central ID: 

Pamenter, M. E., Perkins, G. A., Gu, X. Q., Ellisman, M. H., Haddad, G. G. (2013) DIDS (4,4-diisothiocyanatostilbenedisulphonic acid) induces apoptotic cell death in a hippocampal neuronal cell line and is not neuroprotective against ischemic stress. PLoS One. 10.1371/journal.pone.0060804.

PubMedID: 23577164
PubMed Central ID: 

Konopnicki, C. M., Dickmann, L. J., Tracy, J. M., Tukey, R. H., Wienkers, L. C., Foti, R. S. (2013) Evaluation of UGT protein interactions in human hepatocytes: effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes. Arch Biochem Biophys. 535(2):143-9. doi: 10.1016/j.abb.2013.03.012.

PubMedID: 23562620
PubMed Central ID: 

Glidewell-Kenney, C. A., Shao, P. P., Iyer, A. K., Grove, A. M., Meadows, J. D., Mellon, P. L. (2013) Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol. Endocrinol. 27(3), 437-54.

PubMedID: 23393128
PubMed Central ID: 

Yang, L., Inokuchi, S., Roh, Y. S., Song, J., Loomba, R., Park, E. J., Seki, E. (2013) Transforming growth factor-β signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. Gastroenterology. 144(5), 1042-1054.

PubMedID: 23391818
PubMed Central ID: 

Clark, D. D., Gorman, M. R., Hatori, M., Meadows, J. D., Panda, S., Mellon, P. L. (2013) Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6. J. Biol. Rhythms. 28(1), 15-25.

PubMedID: 23382588
PubMed Central ID: 

Xie, H., Cherrington, B. D., Meadows, J. D., Witham, E. A., Mellon, P. L. (2013) Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development. Mol. Endocrinol. 27(3), 422-36.

PubMedID: 23371388
PubMed Central ID: 

Du, H., Sun, X., Guma, M., Luo, J., Ouyang, H., Zhang, X., Zeng, J., Quach, J., Nguyen, D. H., Shaw, P. X., Karin, M., Zhang, K. (2013) JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc. Natl. Acad. Sci. USA. 110(6), 2377-82.

PubMedID: 23341606
PubMed Central ID: 

Du, H., Sun, X., Guma, M., Luo, J., Ouyang, H., Zhang, X., Zeng, J., Quach, J., Nguyen, D. H., Shaw, P. X., Karin, M., Zhang, K. (2013) JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci USA. 110(6), 2377-82. doi: 10.1073/pnas.1221729110.

PubMedID: 23341606
PubMed Central ID: 

Perkins, G. A., Scott, R., Perez, A., Ellisman, M. H., Johnson, J. E., Fox, D. A.. (2012) Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption. Mol Vis. 18, 3029-48

PubMedID: 23288995
PubMed Central ID: 

Sakurai, T., Kudo, M., Umemura, A., He, G., Elsharkawy, A. M., Seki, E., Karin, M. (2013) p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res. 73(1), 215-24. doi: 10.1158/0008-5472.CAN-12-1602.

PubMedID: 23271722
PubMed Central ID: 

Uhlenhaut, N. H., Barish, G. D., Yu, R. T., Downes, M., Karunasiri, M., Liddle, C., Schwalie, P., Hübner, N., Evans, R. M. (2013) Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. Mol Cell. 49(1):158-71. doi: 10.1016/j.molcel.2012.10.013.

PubMedID: 23159735
PubMed Central ID: 

Yu, G. Y., He, G., Li, C. Y., Tang, M., Grivennikov, S., Tsai, W. T., Wu, M. S., Hsu, C. W., Tsai, Y., Wang, L. H., Karin, M. (2012) Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol. Cell. 48(2), 313-21.

PubMedID: 22959272
PubMed Central ID: 

Yu, G. Y., He, G., Li, C. Y., Tang, M., Grivennikov, S., Tsai, W. T., Wu, M. S., Hsu, C. W., Tsai, Y., Wang, L. H., Karin, M. (2012) Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell. 48(2), 313-21. doi: 10.1016/j.molcel.2012.07.032.

PubMedID: 22959272
PubMed Central ID: 

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H. W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., Wolfe, A. M., Perkins, G. A., Ellisman, M. H., Bier, E., Scadeng, M., Foretz, M., Viollet, B., Olefsky, J., Karin, M. (2012) Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell. Metab. 16(3), 311-21.

PubMedID: 22958918
PubMed Central ID: 

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H. W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., Wolfe, A. M., Perkins, G. A., Ellisman, M. H., Bier, E., Scadeng, M., Foretz, M., Viollet, B., Olefsky, J., Karin, M. (2012) Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 16(3), 311-21. doi: 10.1016/j.cmet.2012.08.004.

PubMedID: 22958918
PubMed Central ID: 

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H. W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., Wolfe, A. M., Perkins, G. A., Ellisman, M., Bier, E., Scadeng, M., Foretz, M., Viollet, B., Olefsky, J., Karin, M. (2012) Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab.16(3), 311-21.

PubMedID: 22958918
PubMed Central ID: 

Li, T., Yu, R. T., Atkins, A. R., Downes, M., Tukey, R. H., Evans, R. M. (2012) Targeting the pregnane X receptor in liver injury. Expert Opin Ther Targets16(11):1075-83. doi: 10.1517/14728222.2012.715634.

PubMedID: 22913318
PubMed Central ID: 

Brayman, M. J., Pepa, P. A., Mellon, P. L. (2012) Androgen receptor repression of gonadotropin-releasing hormone gene transcription via enhancer 1. Mol. Cell. Endocrinol. 363(1-2), 92-9.

PubMedID: 22877652

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