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PubMed Central ID: 
Mendoza-Cózatl, D. G., Xie, Q., Akmakjian, G. Z., Jobe, T. O., Patel, A., Stacey, M. G., Song, L., Demoin, D. W., Jurisson, S. S., Stacey, G., Schroeder, J. I. (2014) OPT3 is a component of the iron-signaling network between leaves and roots and misregulation of OPT3 leads to an over-accumulation of cadmium in seeds. Mol Plant. 7(9), 1455-69.
PubMedID: 24880337
PubMed Central ID: 

Umemura, A., Park, E. J., Taniguchi, K., Lee, J. H., Shalapour, S., Valasek, M. A., Aghajan, M., Nakagawa, H., Seki, E., Hall, M. N., Karin, M. (2014) Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. doi: 10.1016/j.cmet.2014.05.001.

PubMedID: 24910242
PubMed Central ID: 

Konopnicki, C. M., Dickmann, L. J., Tracy, J. M., Tukey, R. H., Wienkers, L. C., Foti, R. S. (2013) Evaluation of UGT protein interactions in human hepatocytes: effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes. Arch Biochem Biophys. 535(2), 143-9.

PubMedID: 23562620
PubMed Central ID: 

Kudoh, K., Uchinami, H., Yoshioka, M., Seki, E., Yamamoto, Y. (2013) Nrf2 Activation Protects the Liver From Ischemia/Reperfusion Injury in Mice. Ann Surg. 260(1),118-27.

PubMedID: 24368646
PubMed Central ID: 

He, G., Dhar, D., Nakagawa, H., Font-Burgada, J., Ogata, H., Jiang, Y., Shalapour, S., Seki, E., Yost, S. E., Jepsen, K., Frazer, K. A., Harismendy, O., Hatziapostolou, M., Iliopoulos, D., Suetsugu, A., Hoffman, R. M., Tateishi, R., Koike, K., Karin, M. (2013) Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 155(2), 384-96.

PubMedID: 24120137
PubMed Central ID: 

Moles, A., Murphy, L., Wilson, C. L., Chakraborty, J. B., Fox, C., Park, E. J., Mann, J., Oakley, F., Howarth, R., Brain, J., Masson, S., Karin, M., Seki, E., Mann, D. A. (2014) A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol. 60(4), 782-91.

PubMedID: 24333183
PubMed Central ID: 

Roh, Y. S., Song, J., Seki, E. (2014) TAK1 regulates hepatic cell survival and carcinogenesis. J. Gastroenterol. 49(2),185-94.

PubMedID: 24443058
PubMed Central ID: 

Yang, L., Roh, Y. S., Song, J., Zhang, B., Liu, C., Loomba, R., Seki, E. (2014) Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. Hepatology. 59(2), 483-95.

PubMedID: 23996730
PubMed Central ID: 

Liu, C., Chen, X., Yang, L., Kisseleva, T., Brenner, D. A., Seki, E. (2014) Transcriptional Repression of the Transforming Growth Factor β (TGF-β) Pseudoreceptor BMP and Activin Membrane-bound Inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 Enhances TGF-β Signaling in Hepatic Stellate Cells. J Biol Chem. 289(10), 7082-91.

PubMedID: 24448807
PubMed Central ID: 

Breen, K. M., Mellon, P. L. (2014) Influence of stress-induced intermediates on gonadotropin gene expression in gonadotrope cells. Mol. Cell. Endocrinol. 385(1-2), 71-7.

PubMedID: 24012628
PubMed Central ID: 

Fan, W., Atkins, A. R., Yu, R. T., Downes, M., Evans, R. M. (2013) Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. J Mol Endocrinol. 51(3), T87-T100.

PubMedID: 24280961
PubMed Central ID: 

Yueh, M. F., Chen, S., Nguyen, N., Tukey, R. H. (2014) Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J Biol Chem. 289(8), 4699-709.

PubMedID: 24403077
PubMed Central ID: 

Chen, S., Yueh, M. F., Bigo, C., Barbier, O., Wang, K., Karin, M., Nguyen, N., Tukey, R. H. (2013) Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci USA. 110,19143-19148. 

PubMedID: 24191041
PubMed Central ID: 

Hauser, F., Chen, W., Deinlein, U., Chang, K., Ossowski, S., Fitz, J., Hannon, G. J., Schroeder, J. I. (2013) A genomic-scale artificial microRNA library as a tool to investigate the functionally redundant gene space in Arabidopsis. Plant Cell. 25(8), 2848-63.

PubMedID: 23956262
PubMed Central ID: 

Madsen, D. H., Leonard, D., Masedunskas, A., Moyer, A., Jürgensen, H. J., Peters, D. E., Amornphimoltham, P., Selvaraj, A., Yamada, S. S., Brenner, D. A., Burgdorf, S., Engelholm, L. H., Behrendt, N., Holmbeck, K., Weigert, R., Bugge, T. H. (2013) M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway J Cell Biol. 202(6), 951-66.

PubMedID: 24019537
PubMed Central ID: 

Yang, L., Inokuchi, S., Roh, Y. S., Song, J., Loomba, R., Park, E. J., Seki, E. (2013) Transforming growth factor-β signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. Gastroenterology. 144(5), 1042-1054.

PubMedID: 23391818
PubMed Central ID: 

Imaizumi, T., Schroeder, J. I., Kay, S. A. (2007) In SYNC: the ins and outs of circadian oscillations in calcium. Sci STKE. 390, pe32

PubMedID: 17565121
PubMed Central ID: 

Imaizumi, T., Kay, S. A., Schroeder, J. I. (2007) Circadian rhythms. Daily watch on metabolism. Science. 318, 730-1731.

PubMedID: 18006706
PubMed Central ID: 

Guo, L., Ghassemian, M., Komives, E. A., Russell, P. (2012) Cadmium-induced proteome remodeling regulated by Spc1/Sty1 and Zip1 in fission yeast. Toxicol Sci. 129(1), 200-12.

PubMedID: 22610605
PubMed Central ID: 

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H. W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., Wolfe, A. M., Perkins, G. A., Ellisman, M. H., Bier, E., Scadeng, M., Foretz, M., Viollet, B., Olefsky, J., Karin, M. (2012) Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell. Metab. 16(3), 311-21.

PubMedID: 22958918
PubMed Central ID: 

Ding, N., Yu, R. T., Subramaniam, N., Sherman, M. H., Wilson, C., Rao, R., Leblanc, M., Coulter, S., He, M., Scott, C., Lau, S. L., Atkins, A. R., Barish, G. D., Gunton, J. E., Liddle, C., Downes, M., Evans, R. M. (2013) A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell. 153(3), 601-13.

PubMedID: 23622244
PubMed Central ID: 

Pamenter, M. E., Perkins, G. A., Gu, X. Q., Ellisman, M. H., Haddad, G. G. (2013) DIDS (4,4-diisothiocyanatostilbenedisulphonic acid) induces apoptotic cell death in a hippocampal neuronal cell line and is not neuroprotective against ischemic stress. PLoS One. 10.1371/journal.pone.0060804.

PubMedID: 23577164
PubMed Central ID: 

Lamia, K. A., Evans, R. M. (2010) Metabolism: Tick, tock, a beta-cell clock. Nature. 466 (7306), 571-2.

PubMedID: 20671699
PubMed Central ID: 

Du, H., Sun, X., Guma, M., Luo, J., Ouyang, H., Zhang, X., Zeng, J., Quach, J., Nguyen, D. H., Shaw, P. X., Karin, M., Zhang, K. (2013) JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci USA. 110(6), 2377-82.

PubMedID: 23341606
PubMed Central ID: 

Yu, G. Y., He, G., Li, C. Y., Tang, M., Grivennikov, S., Tsai, W. T., Wu, M. S., Hsu, C. W., Tsai, Y., Wang, L. H., Karin, M. (2012) Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell. 48(2), 313-21.

PubMedID: 22959272
PubMed Central ID: 

Pohaku Mitchell, K. K., Liberman, A., Kummel, A. C., Trogler, W. C. (2012) Iron(III)-doped, silica nanoshells: a biodegradable form of silica. J Am Chem Soc. 134(34), 13997-4003.

PubMedID: 22871140
PubMed Central ID: 

Fujiwara, R., Chen, S., Karin, M., Tukey, R. H. (2012) Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 142(1), 109-118.

PubMedID: 21983082
PubMed Central ID: 

Noreault-Conti, T. L., Fellows, A., Jacobs, J. M., Trask, H. W., Strom, S. C., Evans, R. M., Wrighton, S. A., Sinclair, P. R., Sinclair, J. F., Nichols, R. C. (2012) Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes. Int Immunopharmacol. 12(4), 651-6.

PubMedID: 22310326
PubMed Central ID: 

Mendoza-Cózatl, D.G., Jobe, T. O., Hauser, F., Schroeder, J. I. (2011) Long-distance transport, vacuolar sequestration, tolerance, and transcriptional responses induced by cadmium and arsenic. Curr Opin Plant Biol. 14(5), 554-62.

PubMedID: 21820943
PubMed Central ID: 

Horie, T., Brodsky, D. E., Costa, A., Kaneko, T., Lo Schiavo, F., Katsuhara, M., Schroeder, J. I. (2011) K+ transport by the OsHKT2;4 transporter from rice with atypical Na+ transport properties and competition in permeation of K+ over Mg2+ and Ca2+ ions. Plant Physiol. 156(3), 1493-507.

PubMedID: 21610181
PubMed Central ID: 

Rodríguez-Gabriel, M. A., Russell, P. (2008) Control of mRNA stability by SAPKs. Top Curr Genet. 20, 159-170.

PubMedID: 21738496
PubMed Central ID: 

Böhmer, M. & Schroeder, J. I. (2011) Quantitative transcriptomic analysis of ABA-induced and ROSdependent expression changes and proteomic profiling in Arabidopsis suspension cells. Plant Journal. 10.1111/j.1365-313X.2011.04579.x. 

PubMedID: 21426425
PubMed Central ID: 

Larder, R., Clark, D. D., Miller, N. L., Mellon, P. L. (2011) Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6. J. Neurosci. 31(2), 426-38.

PubMedID: 21228153
PubMed Central ID: 

Kacevska, M., Downes, M. R., Sharma, R., Evans, R. M., Clarke, S. J., Liddle, C., Robertson, G. R. (2011) Extrahepatic cancer suppresses nuclear receptor-regulated drug metabolism. Clin Cancer Res. 17(10), 3170-80.

PubMedID: 21498392
PubMed Central ID: 

Österreicher, C.H., Penz-Österreicher, M., Grivennikov, S. I., Guma, M., Koltsova, E. K., Datz, C., Sasik, R., Hardiman, G., Karin, M., Brenner, D. A., (2011) Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci USA. 108(1), 308-13.

PubMedID: 21173249
PubMed Central ID: 

Mendoza-Cózatl, D. G., Zhai, Z, Jobe, T. O., Akmakjian, G. Z., Song, W. Y., Limbo, O., Russell, M. R., Kozlovskyy, V. I., Martinoia, E., Vatamaniuk, O. K., Russell, P., Schroeder, J. I. (2010) Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. J Biol Chem. 285(52), 40416-26.

PubMedID: 20937798
PubMed Central ID: 

Suhr, S. T., Chang, E. A., Tjong, J., Alcasid, N., Perkins, G. A., Goissis, M. D., Ellisman, M. H., Perez, G. I., Cibelli, J. B. (2010) Mitochondrial rejuvenation after induced pluripotency. PLoS One. doi: 10.1371/journal.pone.0014095.

PubMedID: 21124794
PubMed Central ID: 

He, L., Perkins, G. A., Poblenz, A. T., Harris, J. B., Hung, M., Ellisman, M. H., Fox, D. A., (2003) Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci USA. 100(3),1022-7

PubMedID: 12540825
PubMed Central ID: 

Lee, J. H., Bodmer, R., Bier, E., Karin, M. (2010) Sestrins at the crossroad between stress and aging. Aging (Albany NY). 2(6), 369-74.

PubMedID: 20606249
PubMed Central ID: 

Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., Karin, M. (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 327(5970),1223-8.

PubMedID: 20203043
PubMed Central ID: 

Miller, N. L., Wevrick, R., Mellon, P. L. (2009)  Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development. Hum. Mol. Genet. 18(2), 248-60.

PubMedID: 18930956
PubMed Central ID: 

Yamaguchi, R., Lartigue, L., Perkins, G., Scott, R. T., Dixit, A., Kushnareva, Y., Kuwana, T., Ellisman, M. H., (2008) Newmeyer DD.Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Mol Cell. 31(4), 557-69.

PubMedID: 18691924
PubMed Central ID: 

Gong, J. M., Lee, D. A., Schroeder, J. I. (2003) Long-distance root-to-shoot transport of phytochelatins and cadmium in Arabidopsis. Proc Natl Acad Sci USA. 100(17), 10118-23.

PubMedID: 12909714
PubMed Central ID: 

Pezzoli, K., Tukey, R., Sarabia, H., Zaslavsky, I., Miranda, M. L., Suk, W. A., Lin, A., Ellisman, M. (2007) The NIEHS Environmental Health Sciences Data Resource Portal: placing advanced technologies in service to vulnerable communities. Environ Health Perspect. 115(4), 564-71.

PubMedID: 17450225
PubMed Central ID: 

Rodríguez-Gabriel, M. A., Watt, S., Bähler, J., Russell, P. (2006) Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast. Mol Cell Biol. 26, 6347-6356.

PubMedID: 16914721
PubMed Central ID: 

Sakurai, T., Maeda, S., Chang, L., Karin, M. (2006)  Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci USA. 103(28),10544-51.

PubMedID: 16807293
PubMed Central ID: 

Chen, A., Komives, E. A., Schroeder, J. I. (2006) An improved grafting technique for mature Arabidopsis plants demonstrates long-distance shoot-to-root transport of phytochelatins in Arabidopsis. Plant Physiology. 141, 108-120.

PubMedID: 16531489
PubMed Central ID: 

Kim, I. H., Kisseleva, T., Brenner, D. A. (2015) Aging and liver disease. Curr Opin Gastroenterol. 31(3), 184-91.

PubMedID: 25850346
PubMed Central ID: 

Mori, I. and Schroeder, J. I. (2004)  Reactive Oxygen Species Activation of Plant Ca2+ Channels: A Signaling Mechanism in Polar Growth, Hormone Transduction, Stress Signaling, and Hypothetically Mechano-transduction. Plant Physiology 135(2), 702-708.

PubMedID: 15208417
PubMed Central ID: 

Sánchez, A., Roguev, A., Krogan, N.J., Russell, P. (2015) Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants. G3 (Bethesda). 5(5), 953-62.

PubMedID: 25795664

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